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10.1242/dmm.030627 http://scihub22266oqcxt.onion/10.1242/dmm.030627 C5665458!5665458!28993311     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dis+Model+Mech 2017 ; 10 (10): 1187-99 Nephropedia Template TP {{tp|p=28993311|t=2017. Central and peripheral circadian clocks and their role in Alzheimer s disease |pdf=|usr=}}{{28993311}} gab.com Text Central and peripheral circadian clocks and their role in Alzheimer s disease JO: Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=28993311 #FOAvip Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face. The workings of this internal clock become impaired with age. In this review, we discuss whether such age-related impairments in the circadian clock interact with age-related neurodegenerative disorders, such as Alzheimer's disease. Findings from mouse and fly models of Alzheimer's disease have accelerated our understanding of the interaction between neurodegeneration and circadian biology. These models show that neurodegeneration likely impairs circadian rhythms either by damaging the central clock or by blocking its communication with other brain areas and with peripheral tissues. The consequent sleep and metabolic deficits could enhance the susceptibility of the brain to further degenerative processes. Thus, circadian dysfunction might be both a cause and an effect of neurodegeneration. We also discuss the primary role of light in the entrainment of the central clock and describe important, alternative time signals, such as food, that play a role in entraining central and peripheral circadian clocks. Finally, we propose how these recent insights could inform efforts to develop novel therapeutic approaches to re-entrain arrhythmic individuals with neurodegenerative disease. Twit Text FOAVip Central and peripheral circadian clocks and their role in Alzheimer s disease ????Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=28993311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28993311 #FOAvip English Wikipedia <ref>{{Cite pmid|28993311}}</ref> Central and peripheral circadian clocks and their role in Alzheimer s disease #MMPMID28993311 Chauhan R; Chen KF; Kent BA; Crowther DC Dis Model Mech 2017[Oct]; 10 (10): 1187-99 PMID28993311show ga Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face. The workings of this internal clock become impaired with age. In this review, we discuss whether such age-related impairments in the circadian clock interact with age-related neurodegenerative disorders, such as Alzheimer's disease. Findings from mouse and fly models of Alzheimer's disease have accelerated our understanding of the interaction between neurodegeneration and circadian biology. These models show that neurodegeneration likely impairs circadian rhythms either by damaging the central clock or by blocking its communication with other brain areas and with peripheral tissues. The consequent sleep and metabolic deficits could enhance the susceptibility of the brain to further degenerative processes. Thus, circadian dysfunction might be both a cause and an effect of neurodegeneration. We also discuss the primary role of light in the entrainment of the central clock and describe important, alternative time signals, such as food, that play a role in entraining central and peripheral circadian clocks. Finally, we propose how these recent insights could inform efforts to develop novel therapeutic approaches to re-entrain arrhythmic individuals with neurodegenerative disease. äCentral and peripheral circadian clocks and their role in Alzheimer s (epmc).pdf DeepDyve Pubget Overpricing