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10.1080/2162402X.2017.1342917 http://scihub22266oqcxt.onion/10.1080/2162402X.2017.1342917 C5665080!5665080!29123952     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2017 ; 6 (10): ä Nephropedia Template TP {{tp|p=29123952|t=2017. Mevalonate metabolism governs cancer immune surveillance |pdf=|usr=}}{{29123952}} gab.com Text Mevalonate metabolism governs cancer immune surveillance JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=29123952 #FOAvip The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs cellular function and survival, whereas hyperactivity can lead to malignant transformation. Here, we first address how mevalonate metabolism drives immunity and then highlight ways of the immune system to respond to both, limited and uncontrolled flux through the mevalonate pathway. Immune responses elicited by mevalonate pathway dysregulation may be harnessed to increase the clinical efficacy of current cancer therapy regimens. Twit Text FOAVip Mevalonate metabolism governs cancer immune surveillance ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=29123952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29123952 #FOAvip English Wikipedia <ref>{{Cite pmid|29123952}}</ref> Mevalonate metabolism governs cancer immune surveillance #MMPMID29123952 Gruenbacher G; Thurnher M Oncoimmunology 2017[]; 6 (10): ä PMID29123952show ga The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs cellular function and survival, whereas hyperactivity can lead to malignant transformation. Here, we first address how mevalonate metabolism drives immunity and then highlight ways of the immune system to respond to both, limited and uncontrolled flux through the mevalonate pathway. Immune responses elicited by mevalonate pathway dysregulation may be harnessed to increase the clinical efficacy of current cancer therapy regimens. äMevalonate metabolism governs cancer immune surveillance (epmc).pdf DeepDyve Pubget Overpricing