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10.1073/pnas.1711596114

http://scihub22266oqcxt.onion/10.1073/pnas.1711596114
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C5664539!5664539!29073107
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suck abstract from ncbi


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pmid29073107      Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (43): E9105-14
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  • Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice #MMPMID29073107
  • Mark Welch JL; Hasegawa Y; McNulty NP; Gordon JI; Borisy GG
  • Proc Natl Acad Sci U S A 2017[Oct]; 114 (43): E9105-14 PMID29073107show ga
  • Spatial structure is postulated to have a powerful influence on establishing and sustaining the signaling and metabolic exchanges that define relationships among members of the gut microbiota and host. However, information about gut community spatial structure is limited. Simultaneous imaging of components of a 15-member model human gut bacterial community over a range of spatial scales in gnotobiotic mice revealed that the colon is better conceptualized as an incompletely mixed bioreactor, rather than having sharply stratified luminal and mucosal compartments. Identifying host and microbial factors that constrain the ability of community members to establish sizeable single or oligotaxon agglomerations should yield new insights about how ?micro?-scale mixing defines community function.
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