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10.1073/pnas.1708447114 http://scihub22266oqcxt.onion/10.1073/pnas.1708447114 C5664520!5664520 !29073069     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29073069 &cmd=llinks): Failed to open stream: HTTP request failed! 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Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect |pdf=|usr=}}{{29073069 }} gab.com Text Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29073069 #FOAvip Aberrant alternative splicing and epigenetic changes are both associated with various cancers, but epigenetic regulation of alternative splicing in cancer is largely unknown. Here we report that the intragenic DNA methylation-mediated binding of Brother of Regulator of Imprinted Sites (BORIS) at the alternative exon of Pyruvate Kinase (PKM) is associated with cancer-specific splicing that promotes the Warburg effect and breast cancer progression. Interestingly, the inhibition of DNA methylation, BORIS depletion, or CRISPR/Cas9-mediated deletion of the BORIS binding site leads to a splicing switch from cancer-specific PKM2 to normal PKM1 isoform. This results in the reversal of the Warburg effect and the inhibition of breast cancer cell growth, which may serve as a useful approach to inhibit the growth of breast cancer cells. Importantly, our results show that in addition to PKM splicing, BORIS also regulates the alternative splicing of several genes in a DNA methylation-dependent manner. Our findings highlight the role of intragenic DNA methylation and DNA binding protein BORIS in cancer-specific splicing and its role in tumorigenesis. Twit Text FOAVip Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29073069 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29073069 #FOAvip English Wikipedia <ref>{{Cite pmid|29073069 }}</ref> Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect #MMPMID29073069 Singh S ; Narayanan SP ; Biswas K ; Gupta A ; Ahuja N ; Yadav S ; Panday RK ; Samaiya A ; Sharan SK ; Shukla S Proc Natl Acad Sci U S A 2017[Oct]; 114 (43 ): 11440-11445 PMID29073069 show ga Aberrant alternative splicing and epigenetic changes are both associated with various cancers, but epigenetic regulation of alternative splicing in cancer is largely unknown. Here we report that the intragenic DNA methylation-mediated binding of Brother of Regulator of Imprinted Sites (BORIS) at the alternative exon of Pyruvate Kinase (PKM) is associated with cancer-specific splicing that promotes the Warburg effect and breast cancer progression. Interestingly, the inhibition of DNA methylation, BORIS depletion, or CRISPR/Cas9-mediated deletion of the BORIS binding site leads to a splicing switch from cancer-specific PKM2 to normal PKM1 isoform. This results in the reversal of the Warburg effect and the inhibition of breast cancer cell growth, which may serve as a useful approach to inhibit the growth of breast cancer cells. Importantly, our results show that in addition to PKM splicing, BORIS also regulates the alternative splicing of several genes in a DNA methylation-dependent manner. Our findings highlight the role of intragenic DNA methylation and DNA binding protein BORIS in cancer-specific splicing and its role in tumorigenesis. |*DNA Methylation [MESH] |Breast Neoplasms/*metabolism [MESH] |Caspases/genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Survival [MESH] |Chromatin Immunoprecipitation [MESH] |DNA-Binding Proteins/genetics/*metabolism [MESH] |DNA/genetics [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Glucose/metabolism [MESH] |Humans [MESH] |Protein Array Analysis [MESH] |RNA Interference [MESH] |RNA, Small Interfering [MESH]Intragenic DNA methylation and BORIS-mediated cancer-specific splicing(epmc).pdf DeepDyve Pubget Overpricing