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10.1073/pnas.1705887114 http://scihub22266oqcxt.onion/10.1073/pnas.1705887114 C5664506!5664506!29073099     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (43): E9026-35 Nephropedia Template TP {{tp|p=29073099|t=2017. Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria |pdf=|usr=}}{{29073099}} gab.com Text Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29073099 #FOAvip Bacterial genomes are extremely diverse in size and composition. Biologists have long sought to explain such variability based on present-day selective and mutational forces. However, mutation rates can change dramatically over time, and experiments with hypermutable bacteria show that their genomes rapidly decay when propagated under the near absence of selection. Whether selection can prevent this decay is unclear. Here, we document the rapid genome decay of hypermutable bacteria even during tens of thousands of generations of sustained adaptation to a laboratory environment. These findings suggest the need to reexamine current ideas about the evolution of bacterial genomes, and they have implications for other hypermutable systems such as viruses and cancer cells. Twit Text FOAVip Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29073099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29073099 #FOAvip English Wikipedia <ref>{{Cite pmid|29073099}}</ref> Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria #MMPMID29073099 Couce A; Caudwell LV; Feinauer C; Hindré T; Feugeas JP; Weigt M; Lenski RE; Schneider D; Tenaillon O Proc Natl Acad Sci U S A 2017[Oct]; 114 (43): E9026-35 PMID29073099show ga Bacterial genomes are extremely diverse in size and composition. Biologists have long sought to explain such variability based on present-day selective and mutational forces. However, mutation rates can change dramatically over time, and experiments with hypermutable bacteria show that their genomes rapidly decay when propagated under the near absence of selection. Whether selection can prevent this decay is unclear. Here, we document the rapid genome decay of hypermutable bacteria even during tens of thousands of generations of sustained adaptation to a laboratory environment. These findings suggest the need to reexamine current ideas about the evolution of bacterial genomes, and they have implications for other hypermutable systems such as viruses and cancer cells. äMutator genomes decay, despite sustained fitness gains, in a long-term(epmc).pdf DeepDyve Pubget Overpricing