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2017 ; 2017
(ä): 4015039
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The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the
Tumor Microenvironment Niche
#MMPMID29181035
Rivera-Cruz CM
; Shearer JJ
; Figueiredo Neto M
; Figueiredo ML
Stem Cells Int
2017[]; 2017
(ä): 4015039
PMID29181035
show ga
Mesenchymal stem cells (MSCs) represent a promising tool for cell therapy,
particularly for their antitumor effects. This cell population can be isolated
from multiple tissue sources and also display an innate ability to home to areas
of inflammation, such as tumors. Upon entry into the tumor microenvironment
niche, MSCs promote or inhibit tumor progression by various mechanisms, largely
through the release of soluble factors. These factors can be immunomodulatory by
activating or inhibiting both the adaptive and innate immune responses. The
mechanisms by which MSCs modulate the immune response are not well understood.
Because of this, the relationship between MSCs and immune cells within the tumor
microenvironment niche continues to be an active area of research in order to
help explain the apparent contradictory findings currently available in the
literature. The ongoing research aims to enhance the potential of MSCs in future
therapeutic applications.