Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29181404
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29181404
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biomed+Res+Int
2017 ; 2017
(ä): 7974149
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
?(9)-Tetrahydrocannabinol Prevents Cardiovascular Dysfunction in STZ-Diabetic
Wistar-Kyoto Rats
#MMPMID29181404
Vella RK
; Jackson DJ
; Fenning AS
Biomed Res Int
2017[]; 2017
(ä): 7974149
PMID29181404
show ga
The aim of this study was to determine if chronic, low-dose administration of a
nonspecific cannabinoid receptor agonist could provide cardioprotective effects
in a model of type I diabetes mellitus. Diabetes was induced in eight-week-old
male Wistar-Kyoto rats via a single intravenous dose of streptozotocin
(65?mg?kg(-1)). Following the induction of diabetes, ?(9)-tetrahydrocannabinol
was administered via intraperitoneal injection (0.15?mg?kg(-1)?day(-1)) for an
eight-week period until the animals reached sixteen weeks of age. Upon completion
of the treatment regime, assessments of vascular reactivity and left ventricular
function and electrophysiology were made, as were serum markers of oxidative
stress and lipid peroxidation. ?(9)-Tetrahydrocannabinol administration to
diabetic animals significantly reduced blood glucose concentrations and
attenuated pathological changes in serum markers of oxidative stress and lipid
peroxidation. Positive changes to biochemical indices in diabetic animals
conferred improvements in myocardial and vascular function. This study
demonstrates that chronic, low-dose administration of ?(9)-tetrahydrocannabinol
can elicit antihyperglycaemic and antioxidant effects in diabetic animals,
leading to improvements in end organ function of the cardiovascular system.
Implications from this study suggest that cannabinoid receptors may be a
potential new target for the treatment of diabetes-induced cardiovascular
disease.
free
free
free
