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10.1038/s41467-017-01355-0 http://scihub22266oqcxt.onion/10.1038/s41467-017-01355-0 C5663922!5663922!29089486     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29089486|t=2017. Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors |pdf=|usr=}}{{29089486}} gab.com Text Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29089486 #FOAvip Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, we build a compendium of 2218 primary tumours across 12 human cancer types and systematically screen for homozygous deletions, aiming to identify rare tumour suppressors. Our analysis defines 96 genomic regions recurrently targeted by homozygous deletions. These recurrent homozygous deletions occur either over tumour suppressors or over fragile sites, regions of increased genomic instability. We construct a statistical model that separates fragile sites from regions showing signatures of positive selection for homozygous deletions and identify candidate tumour suppressors within those regions. We find 16 established tumour suppressors and propose 27 candidate tumour suppressors. Several of these genes (including MGMT, RAD17, and USP44) show prior evidence of a tumour suppressive function. Other candidate tumour suppressors, such as MAFTRR, KIAA1551, and IGF2BP2, are novel. Our study demonstrates how rare tumour suppressors can be identified through copy number meta-analysis. Twit Text FOAVip Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29089486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29089486 #FOAvip English Wikipedia <ref>{{Cite pmid|29089486}}</ref> Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors #MMPMID29089486 Cheng J; Demeulemeester J; Wedge DC; Vollan HKM; Pitt JJ; Russnes HG; Pandey BP; Nilsen G; Nord S; Bignell GR; White KP; Børresen-Dale AL; Campbell PJ; Kristensen VN; Stratton MR; Lingjærde OC; Moreau Y; Van Loo P Nat Commun 2017[]; 8 (ä): ä PMID29089486show ga Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, we build a compendium of 2218 primary tumours across 12 human cancer types and systematically screen for homozygous deletions, aiming to identify rare tumour suppressors. Our analysis defines 96 genomic regions recurrently targeted by homozygous deletions. These recurrent homozygous deletions occur either over tumour suppressors or over fragile sites, regions of increased genomic instability. We construct a statistical model that separates fragile sites from regions showing signatures of positive selection for homozygous deletions and identify candidate tumour suppressors within those regions. We find 16 established tumour suppressors and propose 27 candidate tumour suppressors. Several of these genes (including MGMT, RAD17, and USP44) show prior evidence of a tumour suppressive function. Other candidate tumour suppressors, such as MAFTRR, KIAA1551, and IGF2BP2, are novel. Our study demonstrates how rare tumour suppressors can be identified through copy number meta-analysis. äPan-cancer analysis of homozygous deletions in primary tumours uncover(epmc).pdf DeepDyve Pubget Overpricing