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10.1007/s00018-017-2592-z http://scihub22266oqcxt.onion/10.1007/s00018-017-2592-z C5663815!5663815 !28726057     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28726057 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Life+Sci 2017 ; 74 (24 ): 4561-4572 Nephropedia Template TP {{tp|p=28726057 |t=2017. Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1 |pdf=|usr=}}{{28726057 }} gab.com Text Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1 JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=28726057 #FOAvip Macrophage migration inhibitory factor (MIF), a small conserved protein, is abundant in the immune- and central nervous system (CNS). MIF has several receptors and binding partners that can modulate its action on a cellular level. It is upregulated in neurodegenerative diseases and cancer although its function is far from clear. Here, we report the finding of a new binding partner to MIF, the serine protease HTRA1. This enzyme cleaves several growth factors, extracellular matrix molecules and is implicated in some of the same diseases as MIF. We show that the function of the binding between MIF and HTRA1 is to inhibit the proteolytic activity of HTRA1, modulating the availability of molecules that can change cell growth and differentiation. MIF is therefore the first endogenous inhibitor ever found for HTRA1. It was found that both molecules were present in astrocytes and that the functional binding has the ability to modulate astrocytic activities important in development and disease of the CNS. Twit Text FOAVip Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1 ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=28726057 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28726057 #FOAvip English Wikipedia <ref>{{Cite pmid|28726057 }}</ref> Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1 #MMPMID28726057 Fex Svenningsen Å ; Löring S ; Sørensen AL ; Huynh HUB ; Hjæresen S ; Martin N ; Moeller JB ; Elkjær ML ; Holmskov U ; Illes Z ; Andersson M ; Nielsen SB ; Benedikz E Cell Mol Life Sci 2017[Dec]; 74 (24 ): 4561-4572 PMID28726057 show ga Macrophage migration inhibitory factor (MIF), a small conserved protein, is abundant in the immune- and central nervous system (CNS). MIF has several receptors and binding partners that can modulate its action on a cellular level. It is upregulated in neurodegenerative diseases and cancer although its function is far from clear. Here, we report the finding of a new binding partner to MIF, the serine protease HTRA1. This enzyme cleaves several growth factors, extracellular matrix molecules and is implicated in some of the same diseases as MIF. We show that the function of the binding between MIF and HTRA1 is to inhibit the proteolytic activity of HTRA1, modulating the availability of molecules that can change cell growth and differentiation. MIF is therefore the first endogenous inhibitor ever found for HTRA1. It was found that both molecules were present in astrocytes and that the functional binding has the ability to modulate astrocytic activities important in development and disease of the CNS. |Animals [MESH] |Astrocytes/metabolism/physiology [MESH] |Cell Differentiation/physiology [MESH] |Cell Line [MESH] |Cell Proliferation/physiology [MESH] |Central Nervous System/metabolism/physiology [MESH] |HEK293 Cells [MESH] |High-Temperature Requirement A Serine Peptidase 1 [MESH] |Humans [MESH] |Intramolecular Oxidoreductases/*metabolism [MESH] |Macrophage Migration-Inhibitory Factors/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Protein Binding/physiology [MESH] |Serine Endopeptidases/*metabolism [MESH]Macrophage migration inhibitory factor (MIF) modulates trophic signali(epmc).pdf DeepDyve Pubget Overpricing