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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neurooncol
2017 ; 135
(2
): 361-369
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Do we still need IQ-scores? Misleading interpretations of neurocognitive outcome
in pediatric patients with medulloblastoma: a retrospective study
#MMPMID28779461
Wegenschimmel B
; Leiss U
; Veigl M
; Rosenmayr V
; Formann A
; Slavc I
; Pletschko T
J Neurooncol
2017[Nov]; 135
(2
): 361-369
PMID28779461
show ga
Over the past decades, many studies used global outcome measures like the IQ when
reporting cognitive outcome of pediatric brain tumor patients, assuming that
intelligence is a singular and homogeneous construct. In contrast, especially in
clinical neuropsychology, the assessment and interpretation of distinct
neurocognitive domains emerged as standard. By definition, the full scale IQ
(FIQ) is a score attempting to measure intelligence. It is established by
calculating the average performance of a number of subtests. Therefore, FIQ
depends on the subtests that are used and the influence neurocognitive functions
have on these performances. Consequently, the present study investigated the
impact of neuropsychological domains on the singular "g-factor" concept and
analysed the consequences for interpretation of clinical outcome. The sample
consisted of 37 pediatric patients with medulloblastoma, assessed 0-3 years after
diagnosis with the Wechsler Intelligence Scales. Information processing speed and
visuomotor function were measured by the Trailmaking Test, Form A. Our findings
indicate that FIQ was considerably impacted by processing speed and visuomotor
coordination, which leaded to an underestimation of the general cognitive
performance of many patients. One year after diagnosis, when patients showed the
largest norm-deviation, this effect seemed to be at its peak. As already
recommended in international guidelines, a comprehensive neuropsychological test
battery is necessary to fully understand cognitive outcome. If IQ-tests are used,
a detailed subtest analysis with respect to the impact of processing speed seems
essential. Otherwise patients may be at risk for wrong decision making,
especially in educational guidance.