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2017 ; 7
(4
): 221-226
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Basophils are increased and express increased levels of interleukin-4 in the
parotid lesions of Kimura disease
#MMPMID29094020
Nonaka M
; Sakitani E
; Ono E
; Yamamura Y
; Seo Y
; Shibata N
; Pawankar R
; Yoshihara T
Asia Pac Allergy
2017[Oct]; 7
(4
): 221-226
PMID29094020
show ga
BACKGROUND: Kimura disease (KD) is a systemic soft-tissue disease that leads to
formation of painless masses in lymph nodes, with the highest predilection for
the head and neck and especially the parotid gland. KD lesions are characterized
by marked eosinophil infiltration, production of IgE and increased expression of
T-helper type 2 (Th2) cytokines (interleukin [IL]-4, IL-5, etc.). Skewing to a
Th2 inflammation is also demonstrated in the peripheral blood, with elevated
eosinophils and high IgE levels. It is thought that basophils may play important
roles in orchestrating this Th2 inflammation via IL-4 production leading to the
induction of IgE synthesis as well as eosinophil infiltration. However, there are
no reports as yet on the role of basophils in KD. OBJECTIVE: The present study
was performed to investigate the potential role of basophils in the pathogenesis
of KD. In this context we also examined the expression of IL-4 in basophils in
the KD lesions. METHODS: By immunohistochemistry using a monoclonal antibody
against a basophil marker ProMBP1 we investigated the number and distribution of
basophils in the KD lesions. By double immunohistochemistry we analyzed the
colocalization of IL-4 in basophils. RESULTS: There was an increased number of
basophils infiltrating the KD parotid gland lesions as compared to that in normal
control parotid tissue. By double-immunofluorescence we found that approximately
7% of IL-4-positive cells in KD patients' parotid glands were basophils.
CONCLUSION: Basophils may also play a role in the pathogenesis of KD, leading to
the induction of IgE synthesis and eosinophil infiltration.
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