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10.1186/s40170-017-0171-2 http://scihub22266oqcxt.onion/10.1186/s40170-017-0171-2 C5663111!5663111!29093815     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Metab 2017 ; 5 (ä): ä Nephropedia Template TP {{tp|p=29093815|t=2017. Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids |pdf=|usr=}}{{29093815}} gab.com Text Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids JO: Cancer Metab http://www.kidney.de/pget.php?&tw=1&pmid=29093815 #FOAvip Background: Cancer cells that enter the metastatic cascade require traits that allow them to survive within the circulation and colonize distant organ sites. As disseminating cancer cells adapt to their changing microenvironments, they also modify their metabolism and metabolite production. Methods: A mouse xenograft model of spontaneous tumor metastasis was used to determine the metabolic rewiring that occurs between primary cancers and their metastases. An ?autonomous? mass spectrometry-based untargeted metabolomic workflow with integrative metabolic pathway analysis revealed a number of differentially regulated metabolites in primary mammary fat pad (MFP) tumors compared to microdissected paired lung metastases. The study was further extended to analyze metabolites in paired normal tissues which determined the potential influence of metabolites from the microenvironment. Results: Metabolomic analysis revealed that multiple metabolites were increased in metastases, including cholesterol sulfate and phospholipids (phosphatidylglycerols and phosphatidylethanolamine). Metabolite analysis of normal lung tissue in the mouse model also revealed increased levels of these metabolites compared to tissues from normal MFP and primary MFP tumors, indicating potential extracellular uptake by cancer cells in lung metastases. These results indicate a potential functional importance of cholesterol sulfate and phospholipids in propagating metastasis. In addition, metabolites involved in DNA/RNA synthesis and the TCA cycle were decreased in lung metastases compared to primary MFP tumors. Conclusions: Using an integrated metabolomic workflow, this study identified a link between cholesterol sulfate and phospholipids, metabolic characteristics of the metastatic niche, and the capacity of tumor cells to colonize distant sites. Electronic supplementary material: The online version of this article (10.1186/s40170-017-0171-2) contains supplementary material, which is available to authorized users. Twit Text FOAVip Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids ????Cancer Metab http://www.kidney.de/pget.php?&tw=1&pmid=29093815 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29093815 #FOAvip English Wikipedia <ref>{{Cite pmid|29093815}}</ref> Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids #MMPMID29093815 Johnson CH; Santidrian AF; LeBoeuf SE; Kurczy ME; Rattray NJW; Rattray Z; Warth B; Ritland M; Hoang LT; Loriot C; Higa J; Hansen JE; Felding BH; Siuzdak G Cancer Metab 2017[]; 5 (ä): ä PMID29093815show ga Background: Cancer cells that enter the metastatic cascade require traits that allow them to survive within the circulation and colonize distant organ sites. As disseminating cancer cells adapt to their changing microenvironments, they also modify their metabolism and metabolite production. Methods: A mouse xenograft model of spontaneous tumor metastasis was used to determine the metabolic rewiring that occurs between primary cancers and their metastases. An ?autonomous? mass spectrometry-based untargeted metabolomic workflow with integrative metabolic pathway analysis revealed a number of differentially regulated metabolites in primary mammary fat pad (MFP) tumors compared to microdissected paired lung metastases. The study was further extended to analyze metabolites in paired normal tissues which determined the potential influence of metabolites from the microenvironment. Results: Metabolomic analysis revealed that multiple metabolites were increased in metastases, including cholesterol sulfate and phospholipids (phosphatidylglycerols and phosphatidylethanolamine). Metabolite analysis of normal lung tissue in the mouse model also revealed increased levels of these metabolites compared to tissues from normal MFP and primary MFP tumors, indicating potential extracellular uptake by cancer cells in lung metastases. These results indicate a potential functional importance of cholesterol sulfate and phospholipids in propagating metastasis. In addition, metabolites involved in DNA/RNA synthesis and the TCA cycle were decreased in lung metastases compared to primary MFP tumors. Conclusions: Using an integrated metabolomic workflow, this study identified a link between cholesterol sulfate and phospholipids, metabolic characteristics of the metastatic niche, and the capacity of tumor cells to colonize distant sites. Electronic supplementary material: The online version of this article (10.1186/s40170-017-0171-2) contains supplementary material, which is available to authorized users. äMetabolomics guided pathway analysis reveals link between cancer metas(epmc).pdf DeepDyve Pubget Overpricing