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Pravastatin for prevention of HELLP syndrome: A case report #MMPMID29049209
Otten LA; van der Ven K; Kühr M; Gembruch U; Merz WM
Medicine (Baltimore) 2017[Oct]; 96 (42): ä PMID29049209show ga
Rationale:: Pravastatin has emerged for prevention and treatment of preeclampsia; no reports are available on pravastatin and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. Patient concerns:: The first pregnancy necessitated termination of pregnancy at gestational age (GA) 20+5 for HELLP. Intrauterine fetal death at GA 22+5 occurred in the second pregnancy, whilst on temporizing management of HELLP. Diagnoses:: Severe, recurrent early-onset HELLP syndrome. Interventions:: In her fourth pregnancy, pravastatin was commenced at GA 13. Outcomes:: The course of pregnancy was uncomplicated, and a healthy, appropriate for gestational age fetus was delivered at term. Lessons:: Pravastatin may be effective in prevention of HELLP. The hepatic uptake may be of particular advantage.