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10.1371/journal.pone.0186590 http://scihub22266oqcxt.onion/10.1371/journal.pone.0186590 C5662078!5662078!29084238     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2017 ; 12 (10): ä Nephropedia Template TP {{tp|p=29084238|t=2017. Doliroside A from Dolichos falcata Klein suppressing amyloid ?-protein 42 fibrillogenesis: An insight at molecular level |pdf=|usr=}}{{29084238}} gab.com Text Doliroside A from Dolichos falcata Klein suppressing amyloid -protein 42 fibrillogenesis: An insight at molecular level JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29084238 #FOAvip A bioactive chemical constituent, doliroside A, from Chinese traditional herbal medicine Dolichos falcata Klein was isolated, purified and identified by 60% ethanol extraction, thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. Molecular interaction mechanism between doliroside and amyloid ?42 protein was evaluated by thioflavin T fluorescence (ThT), circular dichroism (CD), atomic force microscope (AFM), and differential scanning calorimeter (DSC) from the aspects of kinetics, secondary structure, morphology, and thermodynamics, respectively. Results show that the purity of doliroside A is 99.9% by HPLC, and its chemical structure is identified by 1H- and 13C-NMR. Doliroside A is observed to be concentration-dependent inhibiting the fibrillation of A?42 with the IC50 value of 26.57 ± 1.6 ?M. CD and DSC results imply that doliroside A can bind to the nuclei and oligomers of A?42 to form a stable complex and suppress A?42 fibrillation. AFM images show that doliroside A, after bound to the nuclei and oligomers, redirect A?42 into off-pathway, amorphous oligomers. These findings not only provide a full insight into the molecular interaction mechanisms between A?42 and doliroside A, but also facilitate the development of new native anti-AD drug of doliroside A compound. Twit Text FOAVip Doliroside A from Dolichos falcata Klein suppressing amyloid -protein 42 fibrillogenesis: An insight at molecular level ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29084238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29084238 #FOAvip English Wikipedia <ref>{{Cite pmid|29084238}}</ref> Doliroside A from Dolichos falcata Klein suppressing amyloid ?-protein 42 fibrillogenesis: An insight at molecular level #MMPMID29084238 Li D; Yu H; Lin Q; Liu Y PLoS One 2017[]; 12 (10): ä PMID29084238show ga A bioactive chemical constituent, doliroside A, from Chinese traditional herbal medicine Dolichos falcata Klein was isolated, purified and identified by 60% ethanol extraction, thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. Molecular interaction mechanism between doliroside and amyloid ?42 protein was evaluated by thioflavin T fluorescence (ThT), circular dichroism (CD), atomic force microscope (AFM), and differential scanning calorimeter (DSC) from the aspects of kinetics, secondary structure, morphology, and thermodynamics, respectively. Results show that the purity of doliroside A is 99.9% by HPLC, and its chemical structure is identified by 1H- and 13C-NMR. Doliroside A is observed to be concentration-dependent inhibiting the fibrillation of A?42 with the IC50 value of 26.57 ± 1.6 ?M. CD and DSC results imply that doliroside A can bind to the nuclei and oligomers of A?42 to form a stable complex and suppress A?42 fibrillation. AFM images show that doliroside A, after bound to the nuclei and oligomers, redirect A?42 into off-pathway, amorphous oligomers. These findings not only provide a full insight into the molecular interaction mechanisms between A?42 and doliroside A, but also facilitate the development of new native anti-AD drug of doliroside A compound. äDoliroside A from Dolichos falcata Klein suppressing amyloid ?-protein(epmc).pdf DeepDyve Pubget Overpricing