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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Card+Anaesth
2017 ; 20
(4
): 408-415
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Comparison of the renoprotective effect of dexmedetomidine and dopamine in
high-risk renal patients undergoing cardiac surgery: A double-blind randomized
study
#MMPMID28994675
Soliman R
; Hussien M
Ann Card Anaesth
2017[Oct]; 20
(4
): 408-415
PMID28994675
show ga
OBJECTIVE: The purpose of the current study was to compare the renoprotective
effects of continuous infusion of dexmedetomidine and dopamine in high-risk renal
patients undergoing cardiac surgery. DESIGN: A double-blind randomized study.
SETTING: Cardiac Centers. PATIENTS: One hundred and fifty patients with baseline
serum creatinine level ?1.4 mg/dl were scheduled for cardiac surgery with
cardiopulmonary bypass. INTERVENTION: The patients were classified into two
groups (each = 75): Group Dex - the patients received a continuous infusion of
dexmedetomidine 0.4 ?g/kg/h without loading dose during the procedure and the
first 24 postoperative hours and Group Dopa - the patients received a continuous
infusion of dopamine 3 ?g/kg/min during the procedure and the first 24
postoperative hours. MEASUREMENTS: The monitors included serum creatinine,
creatinine clearance, blood urea nitrogen, and urine output. MAIN RESULTS: The
creatinine levels and blood urea nitrogen decreased at days 1, 2, 3, 4, and 5 in
Dex group and increased in patients of Dopa group (P < 0.05). The creatinine
clearance increased at days 1, 2, 3, 4, and 5 in Dex group and decreased in
patients of Dopa group (P < 0.05). The amount of urine output was too much higher
in the Dex group than the Dopa group (P < 0.05). CONCLUSIONS: The continuous
infusion of dexmedetomidine during cardiac surgery has a renoprotective effect
and decreased the deterioration in the renal function in high-risk renal patients
compared to the continuous infusion of dopamine.
|Adult
[MESH]
|Aged
[MESH]
|Cardiac Surgical Procedures/*methods
[MESH]
|Cardiopulmonary Bypass
[MESH]
|Cardiotonic Agents/administration & dosage/*therapeutic use
[MESH]
|Creatinine/blood
[MESH]
|Dexmedetomidine/administration & dosage/*therapeutic use
[MESH]
|Dopamine/administration & dosage/*therapeutic use
[MESH]
|Double-Blind Method
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Hypnotics and Sedatives/administration & dosage/*therapeutic use
[MESH]
|Infusions, Intravenous
[MESH]
|Kidney Diseases/complications/*prevention & control
[MESH]