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10.4103/aca.ACA_57_17

http://scihub22266oqcxt.onion/10.4103/aca.ACA_57_17
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suck abstract from ncbi


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pmid28994675
      Ann+Card+Anaesth 2017 ; 20 (4 ): 408-415
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  • Comparison of the renoprotective effect of dexmedetomidine and dopamine in high-risk renal patients undergoing cardiac surgery: A double-blind randomized study #MMPMID28994675
  • Soliman R ; Hussien M
  • Ann Card Anaesth 2017[Oct]; 20 (4 ): 408-415 PMID28994675 show ga
  • OBJECTIVE: The purpose of the current study was to compare the renoprotective effects of continuous infusion of dexmedetomidine and dopamine in high-risk renal patients undergoing cardiac surgery. DESIGN: A double-blind randomized study. SETTING: Cardiac Centers. PATIENTS: One hundred and fifty patients with baseline serum creatinine level ?1.4 mg/dl were scheduled for cardiac surgery with cardiopulmonary bypass. INTERVENTION: The patients were classified into two groups (each = 75): Group Dex - the patients received a continuous infusion of dexmedetomidine 0.4 ?g/kg/h without loading dose during the procedure and the first 24 postoperative hours and Group Dopa - the patients received a continuous infusion of dopamine 3 ?g/kg/min during the procedure and the first 24 postoperative hours. MEASUREMENTS: The monitors included serum creatinine, creatinine clearance, blood urea nitrogen, and urine output. MAIN RESULTS: The creatinine levels and blood urea nitrogen decreased at days 1, 2, 3, 4, and 5 in Dex group and increased in patients of Dopa group (P < 0.05). The creatinine clearance increased at days 1, 2, 3, 4, and 5 in Dex group and decreased in patients of Dopa group (P < 0.05). The amount of urine output was too much higher in the Dex group than the Dopa group (P < 0.05). CONCLUSIONS: The continuous infusion of dexmedetomidine during cardiac surgery has a renoprotective effect and decreased the deterioration in the renal function in high-risk renal patients compared to the continuous infusion of dopamine.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Cardiac Surgical Procedures/*methods [MESH]
  • |Cardiopulmonary Bypass [MESH]
  • |Cardiotonic Agents/administration & dosage/*therapeutic use [MESH]
  • |Creatinine/blood [MESH]
  • |Dexmedetomidine/administration & dosage/*therapeutic use [MESH]
  • |Dopamine/administration & dosage/*therapeutic use [MESH]
  • |Double-Blind Method [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hypnotics and Sedatives/administration & dosage/*therapeutic use [MESH]
  • |Infusions, Intravenous [MESH]
  • |Kidney Diseases/complications/*prevention & control [MESH]
  • |Kidney Function Tests [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Urea/blood [MESH]


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