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10.1111/jcmm.13203 http://scihub22266oqcxt.onion/10.1111/jcmm.13203 C5661260!5661260 !28544332     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28544332 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2017 ; 21 (11 ): 2909-2925 Nephropedia Template TP {{tp|p=28544332 |t=2017. Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling |pdf=|usr=}}{{28544332 }} gab.com Text Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28544332 #FOAvip Ischaemia-reperfusion injury (I/RI) is a common cause of acute kidney injury (AKI). The molecular basis underlying I/RI-induced renal pathogenesis and measures to prevent or reverse this pathologic process remains to be resolved. Basic fibroblast growth factor (FGF2) is reported to have protective roles of myocardial infarction as well as in several other I/R related disorders. Herein we present evidence that FGF2 exhibits robust protective effect against renal histological and functional damages in a rat I/RI model. FGF2 treatment greatly alleviated I/R-induced acute renal dysfunction and largely blunted I/R-induced elevation in serum creatinine and blood urea nitrogen, and also the number of TUNEL-positive tubular cells in the kidney. Mechanistically, FGF2 substantially ameliorated renal I/RI by mitigating several mitochondria damaging parameters including pro-apoptotic alteration of Bcl2/Bax expression, caspase-3 activation, loss of mitochondrial membrane potential and K(ATP) channel integrity. Of note, the protective effect of FGF2 was significantly compromised by the K(ATP) channel blocker 5-HD. Interestingly, I/RI alone resulted in mild activation of FGFR, whereas FGF2 treatment led to more robust receptor activation. More significantly, post-I/RI administration of FGF2 also exhibited robust protection against I/RI by reducing cell apoptosis, inhibiting the release of damage-associated molecular pattern molecule HMBG1 and activation of its downstream inflammatory cytokines such as IL-1?, IL-6 and TNF ?. Taken together, our data suggest that FGF2 offers effective protection against I/RI and improves animal survival by attenuating mitochondrial damage and HMGB1-mediated inflammatory response. Therefore, FGF2 has the potential to be used for the prevention and treatment of I/RI-induced AKI. Twit Text FOAVip Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28544332 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28544332 #FOAvip English Wikipedia <ref>{{Cite pmid|28544332 }}</ref> Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling #MMPMID28544332 Tan XH ; Zheng XM ; Yu LX ; He J ; Zhu HM ; Ge XP ; Ren XL ; Ye FQ ; Bellusci S ; Xiao J ; Li XK ; Zhang JS J Cell Mol Med 2017[Nov]; 21 (11 ): 2909-2925 PMID28544332 show ga Ischaemia-reperfusion injury (I/RI) is a common cause of acute kidney injury (AKI). The molecular basis underlying I/RI-induced renal pathogenesis and measures to prevent or reverse this pathologic process remains to be resolved. Basic fibroblast growth factor (FGF2) is reported to have protective roles of myocardial infarction as well as in several other I/R related disorders. Herein we present evidence that FGF2 exhibits robust protective effect against renal histological and functional damages in a rat I/RI model. FGF2 treatment greatly alleviated I/R-induced acute renal dysfunction and largely blunted I/R-induced elevation in serum creatinine and blood urea nitrogen, and also the number of TUNEL-positive tubular cells in the kidney. Mechanistically, FGF2 substantially ameliorated renal I/RI by mitigating several mitochondria damaging parameters including pro-apoptotic alteration of Bcl2/Bax expression, caspase-3 activation, loss of mitochondrial membrane potential and K(ATP) channel integrity. Of note, the protective effect of FGF2 was significantly compromised by the K(ATP) channel blocker 5-HD. Interestingly, I/RI alone resulted in mild activation of FGFR, whereas FGF2 treatment led to more robust receptor activation. More significantly, post-I/RI administration of FGF2 also exhibited robust protection against I/RI by reducing cell apoptosis, inhibiting the release of damage-associated molecular pattern molecule HMBG1 and activation of its downstream inflammatory cytokines such as IL-1?, IL-6 and TNF ?. Taken together, our data suggest that FGF2 offers effective protection against I/RI and improves animal survival by attenuating mitochondrial damage and HMGB1-mediated inflammatory response. Therefore, FGF2 has the potential to be used for the prevention and treatment of I/RI-induced AKI. |Acute Kidney Injury/*drug therapy/genetics/metabolism/pathology [MESH] |Animals [MESH] |Apoptosis/drug effects/genetics [MESH] |Blood Urea Nitrogen [MESH] |Caspase 3/genetics/metabolism [MESH] |Creatinine/blood [MESH] |Fibroblast Growth Factor 2/*pharmacology [MESH] |Gene Expression Regulation [MESH] |Interleukins/genetics/metabolism [MESH] |Kidney/drug effects/metabolism/pathology [MESH] |Male [MESH] |Membrane Potential, Mitochondrial/drug effects [MESH] |Mitochondria/*drug effects/metabolism/pathology [MESH] |Potassium Channels/genetics/metabolism [MESH] |Protective Agents/*pharmacology [MESH] |Proto-Oncogene Proteins c-bcl-2/genetics/metabolism [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Receptor, Fibroblast Growth Factor, Type 2/genetics/metabolism [MESH] |Reperfusion Injury/*drug therapy/genetics/metabolism/pathology [MESH] |Signal Transduction [MESH] |Tumor Necrosis Factor-alpha/genetics/metabolism [MESH]Fibroblast growth factor 2 protects against renal ischaemia/reperfusio(epmc).pdf DeepDyve Pubget Overpricing