Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29066596
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Physiol+Rep
2017 ; 5
(20
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Abundance, localization, and functional correlates of the advanced glycation
end-product carboxymethyl lysine in human myocardium
#MMPMID29066596
LeWinter MM
; Taatjes D
; Ashikaga T
; Palmer B
; Bishop N
; VanBuren P
; Bell S
; Donaldson C
; Meyer M
; Margulies KB
; Redfield M
; Bull DA
; Zile M
Physiol Rep
2017[Nov]; 5
(20
): ä PMID29066596
show ga
Advanced glycation end-products (AGEs) play a role in the pathophysiology of
diabetes mellitus (DM) and possibly hypertension (HTN). In experimental DM, AGEs
accumulate in myocardium. Little is known about AGEs in human myocardium. We
quantified abundance, localization, and functional correlates of the AGE
carboxymethyl lysine (CML) in left ventricular (LV) myocardium from patients
undergoing coronary bypass grafting (CBG). Immunoelectron microscopy was used to
quantify CML in epicardial biopsies from 98 patients (71 M, 27 F) with HTN,
HTN + DM or neither (controls), all with normal LV ejection fraction. Myofilament
contraction-relaxation function was measured in demembranated myocardial strips.
Echocardiography was used to quantify LV structure and function. We found that
CML was abundant within cardiomyocytes, but minimally associated with
extracellular collagen. CML counts/?m(2) were 14.7% higher in mitochondria than
the rest of the cytoplasm (P < 0.001). There were no significant sex or
diagnostic group differences in CML counts [controls 45.6 ± 3.6/?m(2) (±SEM), HTN
45.8 ± 3.6/?m(2), HTN + DM 49.3 ± 6.2/?m(2); P = 0.85] and no significant
correlations between CML counts and age, HgbA1c or myofilament function indexes.
However, left atrial volume was significantly correlated with CML counts
(r = 0.41, P = 0.004). We conclude that in CBG patients CML is abundant within
cardiomyocytes but minimally associated with collagen, suggesting that AGEs do
not directly modify the stiffness of myocardial collagen. Coexistent HTN or
HTN + DM do not significantly influence CML abundance. The correlation of CML
counts with LAV suggests an influence on diastolic function independent of HTN,
DM or sex whose mechanism remains to be determined.
|Aged
[MESH]
|Case-Control Studies
[MESH]
|Collagen/metabolism
[MESH]
|Coronary Disease/*metabolism
[MESH]
|Female
[MESH]
|Glycation End Products, Advanced/*metabolism
[MESH]
free
free
free
