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10.1111/jcmm.13219 http://scihub22266oqcxt.onion/10.1111/jcmm.13219 C5661113!5661113!28609011     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28609011&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (11): 3076-86 Nephropedia Template TP {{tp|p=28609011|t=2017. The highly pathogenic H5N1 influenza A virus down?regulated several cellular MicroRNAs which target viral genome |pdf=|usr=}}{{28609011}} gab.com Text The highly pathogenic H5N1 influenza A virus down regulated several cellular MicroRNAs which target viral genome JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28609011 #FOAvip Higher and prolonged viral replication is critical for the increased pathogenesis of the highly pathogenic avian influenza (HPAI) subtype of H5N1 influenza A virus (IAV) over the lowly pathogenic H1N1 IAV strain. Recent studies highlighted the considerable roles of cellular miRNAs in host defence against viral infection. In this report, using a 3?UTR reporter system, we identified several putative miRNA target sites buried in the H5N1 virus genome. We found two miRNAs, miR?584?5p and miR?1249, that matched with the PB2 binding sequence. Moreover, we showed that these miRNAs dramatically down?regulated PB2 expression, and inhibited replication of H5N1 and H1N1 IAVs in A549 cells. Intriguingly, these miRNAs expression was differently regulated in A549 cells infected with the H5N1 and H1N1 viruses. Furthermore, transfection of miR?1249 inhibitor enhanced the PB2 expression and promoted the replication of H5N1 and H1N1 IAVs. These results suggest that H5N1 virus may have evolved a mechanism to escape host?mediated inhibition of viral replication through down?regulation of cellular miRNAs, which target its viral genome. Twit Text FOAVip The highly pathogenic H5N1 influenza A virus down regulated several cellular MicroRNAs which target viral genome ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28609011 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28609011 #FOAvip English Wikipedia <ref>{{Cite pmid|28609011}}</ref> The highly pathogenic H5N1 influenza A virus down?regulated several cellular MicroRNAs which target viral genome #MMPMID28609011 Wang R; Zhang Y; Lu J; Xia B; Yang Z; Zhu X; Zhou X; Huang P J Cell Mol Med 2017[Nov]; 21 (11): 3076-86 PMID28609011show ga Higher and prolonged viral replication is critical for the increased pathogenesis of the highly pathogenic avian influenza (HPAI) subtype of H5N1 influenza A virus (IAV) over the lowly pathogenic H1N1 IAV strain. Recent studies highlighted the considerable roles of cellular miRNAs in host defence against viral infection. In this report, using a 3?UTR reporter system, we identified several putative miRNA target sites buried in the H5N1 virus genome. We found two miRNAs, miR?584?5p and miR?1249, that matched with the PB2 binding sequence. Moreover, we showed that these miRNAs dramatically down?regulated PB2 expression, and inhibited replication of H5N1 and H1N1 IAVs in A549 cells. Intriguingly, these miRNAs expression was differently regulated in A549 cells infected with the H5N1 and H1N1 viruses. Furthermore, transfection of miR?1249 inhibitor enhanced the PB2 expression and promoted the replication of H5N1 and H1N1 IAVs. These results suggest that H5N1 virus may have evolved a mechanism to escape host?mediated inhibition of viral replication through down?regulation of cellular miRNAs, which target its viral genome. äThe highly pathogenic H5N1 influenza A virus down?regulated several ce(epmc).pdf DeepDyve Pubget Overpricing