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10.1111/jcmm.13330 http://scihub22266oqcxt.onion/10.1111/jcmm.13330 C5661112!5661112!28941171     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28941171&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (11): 2643-53 Nephropedia Template TP {{tp|p=28941171|t=2017. Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury |pdf=|usr=}}{{28941171}} gab.com Text Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28941171 #FOAvip The current therapeutic strategy for the management of acute myocardial infarction (AMI) is to return blood flow into the occluded coronary artery of the heart, a process defined as reperfusion. However, reperfusion itself can increase mortality rates in AMI patients because of cardiac tissue damage and dysfunction, which is termed ?ischaemia/reperfusion (I/R) injury?. Mitochondria play an important role in myocardial I/R injury as disturbance of mitochondrial dynamics, especially excessive mitochondrial fission, is a predominant cause of cardiac dysfunction. Therefore, pharmacological intervention and therapeutic strategies which modulate the mitochondrial dynamics balance during I/R injury could exert great beneficial effects to the I/R heart. This review comprehensively summarizes and discusses the effects of mitochondrial fission inhibitors as well as mitochondrial fusion promoters on cardiac and mitochondrial function during myocardial I/R injury. The comparison of the effects of both compounds given at different time?points during the course of I/R injury (i.e. prior to ischaemia, during ischaemia and at the reperfusion period) are also summarized and discussed. Finally, this review also details important information which may contribute to clinical practices using these drugs to improve the quality of life in AMI patients. Twit Text FOAVip Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28941171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28941171 #FOAvip English Wikipedia <ref>{{Cite pmid|28941171}}</ref> Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury #MMPMID28941171 Maneechote C; Palee S; Chattipakorn SC; Chattipakorn N J Cell Mol Med 2017[Nov]; 21 (11): 2643-53 PMID28941171show ga The current therapeutic strategy for the management of acute myocardial infarction (AMI) is to return blood flow into the occluded coronary artery of the heart, a process defined as reperfusion. However, reperfusion itself can increase mortality rates in AMI patients because of cardiac tissue damage and dysfunction, which is termed ?ischaemia/reperfusion (I/R) injury?. Mitochondria play an important role in myocardial I/R injury as disturbance of mitochondrial dynamics, especially excessive mitochondrial fission, is a predominant cause of cardiac dysfunction. Therefore, pharmacological intervention and therapeutic strategies which modulate the mitochondrial dynamics balance during I/R injury could exert great beneficial effects to the I/R heart. This review comprehensively summarizes and discusses the effects of mitochondrial fission inhibitors as well as mitochondrial fusion promoters on cardiac and mitochondrial function during myocardial I/R injury. The comparison of the effects of both compounds given at different time?points during the course of I/R injury (i.e. prior to ischaemia, during ischaemia and at the reperfusion period) are also summarized and discussed. Finally, this review also details important information which may contribute to clinical practices using these drugs to improve the quality of life in AMI patients. äRoles of mitochondrial dynamics modulators in cardiac ischaemia/reperf(epmc).pdf DeepDyve Pubget Overpricing