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10.1111/jcmm.13189 http://scihub22266oqcxt.onion/10.1111/jcmm.13189 C5661111!5661111!28444861     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (11): 2732-47 Nephropedia Template TP {{tp|p=28444861|t=2017. LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose?induced podocyte injury via its interplay with ??catenin |pdf=|usr=}}{{28444861}} gab.com Text LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose induced podocyte injury via its interplay with catenin JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28444861 #FOAvip Metastasis associated lung adenocarcinoma transcript 1(MALAT1) is a long non?coding RNA, broadly expressed in mammalian tissues including kidney and up?regulated in a variety of cancer cells. To date, its functions in podocytes are largely unknown. ??catenin is a key mediator in the canonical and non?canonical Wnt signalling pathway; its aberrant expression promotes podocyte malfunction and albuminuria, and contributes to kidney fibrosis. In this study, we found that MALAT1 levels were increased in kidney cortices from C57BL/6 mice with streptozocin (STZ)?induced diabetic nephropathy, and dynamically regulated in cultured mouse podocytes stimulated with high glucose, which showed a trend from rise to decline. The decline of MALAT1 levels was accompanied with ??catenin translocation to the nuclei and enhanced expression of serine/arginine splicing factor 1 (SRSF1), a MALAT1 RNA?binding protein. Further we showed early interference with MALAT1 siRNA partially restored podocytes function and prohibited ??catenin nuclear accumulation and SRSF1 overexpression. Intriguingly, we showed that ??catenin was involved in MALAT1 transcription by binding to the promotor region of MALAT1; ??catenin knock?down also decreased MALAT1 levels, suggesting a novel feedback regulation between MALAT1 and ??catenin. Notably, ??catenin deletion had limited effects on SRSF1 expression, demonstrating ??catenin might serve as a downstream signal of SRSF1. These findings provided evidence for a pivotal role of MALAT1 in diabetic nephropathy and high glucose?induced podocyte damage. Twit Text FOAVip LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose induced podocyte injury via its interplay with catenin ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28444861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28444861 #FOAvip English Wikipedia <ref>{{Cite pmid|28444861}}</ref> LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose?induced podocyte injury via its interplay with ??catenin #MMPMID28444861 Hu M; Wang R; Li X; Fan M; Lin J; Zhen J; Chen L; Lv Z J Cell Mol Med 2017[Nov]; 21 (11): 2732-47 PMID28444861show ga Metastasis associated lung adenocarcinoma transcript 1(MALAT1) is a long non?coding RNA, broadly expressed in mammalian tissues including kidney and up?regulated in a variety of cancer cells. To date, its functions in podocytes are largely unknown. ??catenin is a key mediator in the canonical and non?canonical Wnt signalling pathway; its aberrant expression promotes podocyte malfunction and albuminuria, and contributes to kidney fibrosis. In this study, we found that MALAT1 levels were increased in kidney cortices from C57BL/6 mice with streptozocin (STZ)?induced diabetic nephropathy, and dynamically regulated in cultured mouse podocytes stimulated with high glucose, which showed a trend from rise to decline. The decline of MALAT1 levels was accompanied with ??catenin translocation to the nuclei and enhanced expression of serine/arginine splicing factor 1 (SRSF1), a MALAT1 RNA?binding protein. Further we showed early interference with MALAT1 siRNA partially restored podocytes function and prohibited ??catenin nuclear accumulation and SRSF1 overexpression. Intriguingly, we showed that ??catenin was involved in MALAT1 transcription by binding to the promotor region of MALAT1; ??catenin knock?down also decreased MALAT1 levels, suggesting a novel feedback regulation between MALAT1 and ??catenin. Notably, ??catenin deletion had limited effects on SRSF1 expression, demonstrating ??catenin might serve as a downstream signal of SRSF1. These findings provided evidence for a pivotal role of MALAT1 in diabetic nephropathy and high glucose?induced podocyte damage. äLncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in (epmc).pdf DeepDyve Pubget Overpricing