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Biochemical Underpinnings of Immune Cell Metabolic Phenotypes #MMPMID28514672
Olenchock BA; Rathmell JC; Vander Heiden MG
Immunity 2017[May]; 46 (5): 703-13 PMID28514672show ga
The metabolism of immune cells affects their function and influences host immunity. This review explores how immune cell metabolic phenotypes reflect biochemical dependencies, and highlights evidence that the metabolic state of immune cells and nutrient availability can both alter immune responses. The central importance of oxygen, energetics, and redox homeostasis in immune cell metabolism, and how these factors are reflected in different metabolic phenotypes, is also discussed. Linking immune cell metabolic phenotype to effector functions is important to understand how altering metabolism can impact the way in which immune cells meet their metabolic demands and affect the immune response in various disease contexts.