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10.1038/s41564-017-0034-1 http://scihub22266oqcxt.onion/10.1038/s41564-017-0034-1 C5660622!5660622!28924146     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Microbiol 2017 ; 2 (11): 1500-6 Nephropedia Template TP {{tp|p=28924146|t=2017. APOLs with low pH dependence can kill all African trypanosomes |pdf=|usr=}}{{28924146}} gab.com Text APOLs with low pH dependence can kill all African trypanosomes JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28924146 #FOAvip The primate-specific serum protein apolipoprotein L1 (APOL1) is the only secreted member of a family of cell death promoting proteins1?4. APOL1 kills the bloodstream parasite Trypanosoma brucei brucei, but not the human sleeping sickness agents T.b. rhodesiense and T.b. gambiense3. We considered the possibility that intracellular members of the APOL1 family, against which extracellular trypanosomes could not have evolved resistance, could kill pathogenic T. brucei subspecies. Here we show that recombinant APOL3 (rAPOL3) kills all African trypanosomes including T.b. rhodesiense, T.b. gambiense and the animal pathogens T. evansi,T. congolense and T. vivax. In contrast, rAPOL3 did not kill more distant trypanosomes such as T. theileri or T. cruzi. This trypanolytic potential was partially shared by rAPOL1 from Papio papio (rPpAPOL1). The differential killing ability between rAPOL3 and rAPOL1 was associated with distinct dependence on acidic pH for activity. Due to both instability and toxicity when injected into mice rAPOL3 cannot be used for treatment of infection, but an experimental rPpAPOL1 mutant inspired by APOL3 exhibited enhanced trypanolytic activity in vitro and ability to completely inhibit T.b. gambiense infection in mice. We conclude that pH dependence influences the trypanolytic potential of rAPOLs. Twit Text FOAVip APOLs with low pH dependence can kill all African trypanosomes ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28924146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28924146 #FOAvip English Wikipedia <ref>{{Cite pmid|28924146}}</ref> APOLs with low pH dependence can kill all African trypanosomes #MMPMID28924146 Fontaine F; Lecordier L; Vanwalleghem G; Uzureau P; Van Reet N; Fontaine M; Tebabi P; Vanhollebeke B; Büscher P; Pérez-Morga D; Pays E Nat Microbiol 2017[Nov]; 2 (11): 1500-6 PMID28924146show ga The primate-specific serum protein apolipoprotein L1 (APOL1) is the only secreted member of a family of cell death promoting proteins1?4. APOL1 kills the bloodstream parasite Trypanosoma brucei brucei, but not the human sleeping sickness agents T.b. rhodesiense and T.b. gambiense3. We considered the possibility that intracellular members of the APOL1 family, against which extracellular trypanosomes could not have evolved resistance, could kill pathogenic T. brucei subspecies. Here we show that recombinant APOL3 (rAPOL3) kills all African trypanosomes including T.b. rhodesiense, T.b. gambiense and the animal pathogens T. evansi,T. congolense and T. vivax. In contrast, rAPOL3 did not kill more distant trypanosomes such as T. theileri or T. cruzi. This trypanolytic potential was partially shared by rAPOL1 from Papio papio (rPpAPOL1). The differential killing ability between rAPOL3 and rAPOL1 was associated with distinct dependence on acidic pH for activity. Due to both instability and toxicity when injected into mice rAPOL3 cannot be used for treatment of infection, but an experimental rPpAPOL1 mutant inspired by APOL3 exhibited enhanced trypanolytic activity in vitro and ability to completely inhibit T.b. gambiense infection in mice. We conclude that pH dependence influences the trypanolytic potential of rAPOLs. äAPOLs with low pH dependence can kill all African trypanosomes (epmc).pdf DeepDyve Pubget Overpricing