Current concepts in eosinophilic esophagitis #MMPMID29104849
Simon D; Straumann A; Schoepfer AM; Simon HU
Allergo J Int 2017[]; 26 (7): 258-66 PMID29104849show ga
Background: Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration. Methods: This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE. Results: EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization. Barrier dysfunction and T?helper 2 inflammation are considered to be pathogenetically important factors. Recently, a proton pump inhibitor (PPI)-sensitive EoE subtype as well as an EoE-like disorder have been described. Conclusion: Research in recent years has contributed to a better understanding of the disease spectrum and pathogenesis of EoE, including genetic dispositions, thereby laying the foundation for innovative treatment approaches.