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10.3389/fmolb.2017.00071 http://scihub22266oqcxt.onion/10.3389/fmolb.2017.00071 C5660096!5660096!29109951     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Mol+Biosci 2017 ; 4 (ä): ä Nephropedia Template TP {{tp|p=29109951|t=2017. RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate |pdf=|usr=}}{{29109951}} gab.com Text RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate JO: Front Mol Biosci http://www.kidney.de/pget.php?&tw=1&pmid=29109951 #FOAvip mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3? untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications (PTMs) can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches. Twit Text FOAVip RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate ????Front Mol Biosci http://www.kidney.de/pget.php?&tw=1&pmid=29109951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29109951 #FOAvip English Wikipedia <ref>{{Cite pmid|29109951}}</ref> RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate #MMPMID29109951 García-Mauriño SM; Rivero-Rodríguez F; Velázquez-Cruz A; Hernández-Vellisca M; Díaz-Quintana A; De la Rosa MA; Díaz-Moreno I Front Mol Biosci 2017[]; 4 (ä): ä PMID29109951show ga mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3? untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications (PTMs) can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches. äRNA Binding Protein Regulation and Cross-Talk in the Control of AU-ric(epmc).pdf DeepDyve Pubget Overpricing