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10.1038/nchembio.2478 http://scihub22266oqcxt.onion/10.1038/nchembio.2478 C5659745!5659745!28920930     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28920930&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Chem+Biol 2017 ; 13 (11): 1179-86 Nephropedia Template TP {{tp|p=28920930|t=2017. GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle |pdf=|usr=}}{{28920930}} gab.com Text GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28920930 #FOAvip The GATOR1/SEACIT complex consisting of Iml1-Npr2-Npr3 inhibits Target of Rapamycin Complex 1 (TORC1) in response to amino acid insufficiency. In glucose medium, Saccharomyces cerevisiae mutants lacking the function of this complex grow poorly in the absence of amino acid supplementation, despite hallmarks of increased TORC1 signaling. Such mutants perceive they are amino acid-replete and thus repress metabolic activities that are important for achieving this state. We find that npr2? mutants have defective mitochondrial TCA cycle activity and retrograde response. Supplementation of glutamine, and especially aspartate, which are nitrogen-containing forms of TCA cycle intermediates, rescue growth of npr2? mutants. These amino acids are then consumed in biosynthetic pathways that require nitrogen to support proliferative metabolism. Our findings reveal that negative regulators of TORC1 such as GATOR1/SEACIT regulate the cataplerotic synthesis of these amino acids from the TCA cycle in tune with the amino acid and nitrogen status of cells. Twit Text FOAVip GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28920930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28920930 #FOAvip English Wikipedia <ref>{{Cite pmid|28920930}}</ref> GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle #MMPMID28920930 Chen J; Sutter BM; Shi L; Tu BP Nat Chem Biol 2017[Nov]; 13 (11): 1179-86 PMID28920930show ga The GATOR1/SEACIT complex consisting of Iml1-Npr2-Npr3 inhibits Target of Rapamycin Complex 1 (TORC1) in response to amino acid insufficiency. In glucose medium, Saccharomyces cerevisiae mutants lacking the function of this complex grow poorly in the absence of amino acid supplementation, despite hallmarks of increased TORC1 signaling. Such mutants perceive they are amino acid-replete and thus repress metabolic activities that are important for achieving this state. We find that npr2? mutants have defective mitochondrial TCA cycle activity and retrograde response. Supplementation of glutamine, and especially aspartate, which are nitrogen-containing forms of TCA cycle intermediates, rescue growth of npr2? mutants. These amino acids are then consumed in biosynthetic pathways that require nitrogen to support proliferative metabolism. Our findings reveal that negative regulators of TORC1 such as GATOR1/SEACIT regulate the cataplerotic synthesis of these amino acids from the TCA cycle in tune with the amino acid and nitrogen status of cells. äGATOR1 regulates nitrogenic cataplerotic reactions of the mitochondria(epmc).pdf DeepDyve Pubget Overpricing