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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Emerg+Top+Life+Sci 2017 ; 1 (1): 75-83 Nephropedia Template TP
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Can t you hear me knocking: contact-dependent competition and cooperation in bacteria #MMPMID29085916
Jones AM; Low DA; Hayes CS
Emerg Top Life Sci 2017[Apr]; 1 (1): 75-83 PMID29085916show ga
Microorganisms are in constant competition for growth niches and environmental resources. In Gram-negative bacteria, contact-dependent growth inhibition (CDI) systems link the fate of one cell with its immediate neighbor through touch-dependent, receptor-mediated toxin delivery. Though discovered for their ability to confer a competitive growth advantage, CDI systems also play significant roles in inter-sibling cooperation, promoting both auto-aggregation and biofilm formation. In this review, we detail the mechanisms of CDI toxin delivery and consider how toxin exchange between isogenic sibling cells could regulate gene expression.