Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29073212
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Statins and new-onset atrial fibrillation in a cohort of patients with
hypertension Analysis of electronic health records, 2006-2015
#MMPMID29073212
Alves-Cabratosa L
; García-Gil M
; Comas-Cufí M
; Ponjoan A
; Martí-Lluch R
; Parramon D
; Blanch J
; Elosua-Bayes M
; Ramos R
PLoS One
2017[]; 12
(10
): e0186972
PMID29073212
show ga
Hypertension is the most prevalent risk factor for new-onset atrial fibrillation
(AF). But few studies have addressed the effect of statins on the incidence of
this arrhythmia in patients with hypertension. This study aimed to evaluate the
effect of statins on new-onset of this arrhythmia in a hypertensive population,
accounting for AF risk. Data from the Information System for the Development of
Research in Primary Care was used to recruit a retrospective cohort of
?55-year-old hypertensive individuals with no ischemic vascular disease, in
2006-2007, followed up through 2015. The effect of initiating statin treatment on
new-onset atrial fibrillation was assessed with Cox proportional hazards models
adjusted by the propensity score of receiving statin treatment, in the overall
study population and stratified by AF risk. Of 100 276 included participants,
9814 initiated statin treatment. The AF incidence per 1000 person-years (95%
confidence interval) was 12.5 (12.3-12.8). Statin use associated with a
significant (9%) reduction in AF incidence. Differences in absolute AF incidence
were higher in the highest AF risk subgroup, and the estimated number needed to
treat to avoid one case was 720. The relative effect was poor, similar across
groups, and non-significant, as was the association of statins with adverse
effects. We found a limited protective effect of statins over new-onset AF in
this hypertensive population with no ischemic vascular disease. If there is no
further indication, hypertensive patients would not benefit from statin use
solely for AF primary prevention.
free
free
free
