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10.1038/ncb3615 http://scihub22266oqcxt.onion/10.1038/ncb3615 C5658024!5658024!28920955     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2017 ; 19 (10): 1286-96 Nephropedia Template TP {{tp|p=28920955|t=2017. miR25/93 mediates hypoxia-induced immunosuppression by repressing cGAS |pdf=|usr=}}{{28920955}} gab.com Text miR25/93 mediates hypoxia-induced immunosuppression by repressing cGAS JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28920955 #FOAvip The mechanisms by which hypoxic tumors evade immunological pressure and anti-tumor immunity remain elusive. Here, we report that two hypoxia-responsive microRNAs, miR25 and miR93, are important for establishing an immunosuppressive tumor microenvironment by down-regulating expression of the DNA-sensor cGAS. Mechanistically, miR25/93 targets NCOA3, an epigenetic factor that maintains basal levels of cGAS expression, leading to repression of cGAS upon hypoxia. This allows hypoxic tumor cells to escape immunological responses induced by damage-associated molecular pattern molecules (DAMPs), specifically the release of mtDNA. Moreover, restoring cGAS expression results in an anti-tumor immune response. Clinically, decreased levels of cGAS are associated with poor prognosis for patients with breast cancer harboring high levels of miR25/93. Together, these data suggest that inactivation of the cGAS pathway plays a critical role in tumor progression, and reveals a direct link between hypoxia-responsive miRNAs and adaptive immune responses to the hypoxic tumor microenvironment, thus unveiling potential new therapeutic strategies. Twit Text FOAVip miR25/93 mediates hypoxia-induced immunosuppression by repressing cGAS ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28920955 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28920955 #FOAvip English Wikipedia <ref>{{Cite pmid|28920955}}</ref> miR25/93 mediates hypoxia-induced immunosuppression by repressing cGAS #MMPMID28920955 Wu MZ; Cheng WC; Chen SF; Nieh S; O?Connor C; Liu CL; Tsai WW; Wu CJ; Martin L; Lin YS; Wu KJ; Lu LF; Belmonte JCI Nat Cell Biol 2017[Oct]; 19 (10): 1286-96 PMID28920955show ga The mechanisms by which hypoxic tumors evade immunological pressure and anti-tumor immunity remain elusive. Here, we report that two hypoxia-responsive microRNAs, miR25 and miR93, are important for establishing an immunosuppressive tumor microenvironment by down-regulating expression of the DNA-sensor cGAS. Mechanistically, miR25/93 targets NCOA3, an epigenetic factor that maintains basal levels of cGAS expression, leading to repression of cGAS upon hypoxia. This allows hypoxic tumor cells to escape immunological responses induced by damage-associated molecular pattern molecules (DAMPs), specifically the release of mtDNA. Moreover, restoring cGAS expression results in an anti-tumor immune response. Clinically, decreased levels of cGAS are associated with poor prognosis for patients with breast cancer harboring high levels of miR25/93. Together, these data suggest that inactivation of the cGAS pathway plays a critical role in tumor progression, and reveals a direct link between hypoxia-responsive miRNAs and adaptive immune responses to the hypoxic tumor microenvironment, thus unveiling potential new therapeutic strategies. ämiR25/93 mediates hypoxia-induced immunosuppression by repressing cGAS(epmc).pdf DeepDyve Pubget Overpricing