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10.1016/j.molmed.2017.05.003 http://scihub22266oqcxt.onion/10.1016/j.molmed.2017.05.003 C5657340!5657340!28648185     free     free     free       Trends+Mol+Med 2017 ; 23 (7): 636-50 Nephropedia Template TP {{tp|p=28648185|t=2017. Exosomes as Reconfigurable Therapeutic Systems |pdf=|usr=}}{{28648185}} gab.com Text Exosomes as Reconfigurable Therapeutic Systems JO: Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28648185 #FOAvip Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ?exosomes?. Generated intracellularly, and defined simply as nano-particulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely, the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. Twit Text FOAVip Exosomes as Reconfigurable Therapeutic Systems ????Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28648185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28648185 #FOAvip English Wikipedia <ref>{{Cite pmid|28648185}}</ref> Exosomes as Reconfigurable Therapeutic Systems #MMPMID28648185 Conlan RS; Pisano S; Oliveira MI; Ferrari M; Pinto IM Trends Mol Med 2017[Jul]; 23 (7): 636-50 PMID28648185show ga Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ?exosomes?. Generated intracellularly, and defined simply as nano-particulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely, the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. äExosomes as Reconfigurable Therapeutic Systems (epmc).pdf DeepDyve Pubget Overpricing