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10.1111/dom.12978 http://scihub22266oqcxt.onion/10.1111/dom.12978 C5655780!5655780 !28432751     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28432751 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Diabetes+Obes+Metab 2017 ; 19 (11 ): 1579-1586 Nephropedia Template TP {{tp|p=28432751 |t=2017. Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study |pdf=|usr=}}{{28432751 }} gab.com Text Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study JO: Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=28432751 #FOAvip AIMS: Metformin is renally excreted and has been associated with the development of lactic acidosis. Although current advice is to omit metformin during illnesses that may increase the risk of acute kidney injury (AKI), the evidence supporting this is lacking. We investigated the relationship between AKI, lactate concentrations and the risk of lactic acidosis in those exposed to metformin. MATERIALS AND METHODS: We undertook a population-based case-control study of lactic acidosis in 1746 participants with Type 2 diabetes and 846 individuals without diabetes with clinically measured lactates with and without AKI between 1994 and 2014. AKI was stratified by severity according to "Kidney Disease: Improving Global Outcomes" guidelines. Mixed-effects logistic and linear regression were used to analyse lactic acidosis risk and lactate concentrations, respectively. RESULTS: Eighty-two cases of lactic acidosis were identified. In Type 2 diabetes, those treated with metformin had a greater incidence of lactic acidosis [45.7 per 100?000 patient years; 95% confidence interval (CI) 35.9-58.3] compared to those not exposed to this drug (11.8 per 100?000 patient years; 95% CI 4.9-28.5). Lactate concentrations were 0.34?mmol/L higher in the metformin-exposed cohort (P?<?.001). The risk of lactic acidosis was higher in metformin users [odds ratio (OR) 2.3; P?=?.002] and increased with AKI severity (stage 1: OR 3.0, P?=?.002; stage 2: OR 9.4, P?<?.001; stage 3: OR 16.1, P?<?.001). CONCLUSIONS: A clear association was found between metformin, lactate accumulation and the development of lactic acidosis. This relationship is strongest in those with AKI. These results provide robust evidence to support current recommendations to omit metformin in any illness that may precipitate AKI. Twit Text FOAVip Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study ????Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=28432751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28432751 #FOAvip English Wikipedia <ref>{{Cite pmid|28432751 }}</ref> Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study #MMPMID28432751 Connelly PJ ; Lonergan M ; Soto-Pedre E ; Donnelly L ; Zhou K ; Pearson ER Diabetes Obes Metab 2017[Nov]; 19 (11 ): 1579-1586 PMID28432751 show ga AIMS: Metformin is renally excreted and has been associated with the development of lactic acidosis. Although current advice is to omit metformin during illnesses that may increase the risk of acute kidney injury (AKI), the evidence supporting this is lacking. We investigated the relationship between AKI, lactate concentrations and the risk of lactic acidosis in those exposed to metformin. MATERIALS AND METHODS: We undertook a population-based case-control study of lactic acidosis in 1746 participants with Type 2 diabetes and 846 individuals without diabetes with clinically measured lactates with and without AKI between 1994 and 2014. AKI was stratified by severity according to "Kidney Disease: Improving Global Outcomes" guidelines. Mixed-effects logistic and linear regression were used to analyse lactic acidosis risk and lactate concentrations, respectively. RESULTS: Eighty-two cases of lactic acidosis were identified. In Type 2 diabetes, those treated with metformin had a greater incidence of lactic acidosis [45.7 per 100?000 patient years; 95% confidence interval (CI) 35.9-58.3] compared to those not exposed to this drug (11.8 per 100?000 patient years; 95% CI 4.9-28.5). Lactate concentrations were 0.34?mmol/L higher in the metformin-exposed cohort (P? |Acidosis, Lactic/blood/*chemically induced/epidemiology [MESH] |Acute Kidney Injury/blood/*chemically induced/epidemiology [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Case-Control Studies [MESH] |Diabetes Mellitus, Type 2/blood/*drug therapy/epidemiology [MESH] |Diabetic Nephropathies/blood/*chemically induced/epidemiology [MESH] |Female [MESH] |Humans [MESH] |Incidence [MESH] |Lactic Acid/*blood [MESH] |Male [MESH] |Metformin/*therapeutic use [MESH]Acute kidney injury, plasma lactate concentrations and lactic acidosis(epmc).pdf DeepDyve Pubget Overpricing