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10.1371/journal.pone.0186636 http://scihub22266oqcxt.onion/10.1371/journal.pone.0186636 C5655426!5655426 !29065138     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29065138 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (10 ): e0186636 Nephropedia Template TP {{tp|p=29065138 |t=2017. In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells |pdf=|usr=}}{{29065138 }} gab.com Text In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29065138 #FOAvip The progression of Alzheimer's disease is causatively linked to the accumulation of amyloid-? aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the death of neuronal cells. The in vitro toxic effects of amyloid peptides are most commonly examined using the human neuroblastoma derived SH-SY5Y cell line and here we show that differentiated neuron-like SH-SY5Y cells are more sensitive to amyloid peptides than non-differentiated cells, because the latter lack long neurites. Exogenous soluble amyloid-? 1-42 covered cell bodies and whole neurites in differentiated cells with dense fibrils, causing neurite beading and fragmentation, whereas preformed amyloid-? 1-42 fibrils had no toxic effects. Importantly, spontaneously fibrillizing amyloid-? 1-42 peptide exhibited substantially higher cellular toxicity than amyloid-? 1-40, which did not form fibrils under the experimental conditions. These results support the hypothesis that peptide toxicity is related to the active fibrillization process in the incubation mixture. Twit Text FOAVip In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29065138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29065138 #FOAvip English Wikipedia <ref>{{Cite pmid|29065138 }}</ref> In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells #MMPMID29065138 Krishtal J ; Bragina O ; Metsla K ; Palumaa P ; Tõugu V PLoS One 2017[]; 12 (10 ): e0186636 PMID29065138 show ga The progression of Alzheimer's disease is causatively linked to the accumulation of amyloid-? aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the death of neuronal cells. The in vitro toxic effects of amyloid peptides are most commonly examined using the human neuroblastoma derived SH-SY5Y cell line and here we show that differentiated neuron-like SH-SY5Y cells are more sensitive to amyloid peptides than non-differentiated cells, because the latter lack long neurites. Exogenous soluble amyloid-? 1-42 covered cell bodies and whole neurites in differentiated cells with dense fibrils, causing neurite beading and fragmentation, whereas preformed amyloid-? 1-42 fibrils had no toxic effects. Importantly, spontaneously fibrillizing amyloid-? 1-42 peptide exhibited substantially higher cellular toxicity than amyloid-? 1-40, which did not form fibrils under the experimental conditions. These results support the hypothesis that peptide toxicity is related to the active fibrillization process in the incubation mixture. |*Apoptosis [MESH] |*Cell Differentiation [MESH] |*Neurites [MESH] |Amyloid beta-Peptides/*metabolism [MESH] |Brain-Derived Neurotrophic Factor/metabolism [MESH] |Cell Line, Tumor [MESH] |Humans [MESH]In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration an(epmc).pdf DeepDyve Pubget Overpricing