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10.1007/s12192-017-0805-x http://scihub22266oqcxt.onion/10.1007/s12192-017-0805-x C5655365!5655365 !28512729     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28512729 &cmd=llinks): Failed to open stream: HTTP request failed! 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Protective effects of Nebivolol against interleukin-1? (IL-1?)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13) |pdf=|usr=}}{{28512729 }} gab.com Text Protective effects of Nebivolol against interleukin-1 (IL-1 )-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13) JO: Cell Stress Chaperones http://www.kidney.de/pget.php?&tw=1&pmid=28512729 #FOAvip The pathological progression of osteoarthritis (OA) involves degradation of articular cartilage matrix. Type II collagen is the main component of cartilage matrix, which is degraded by pro-inflammatory cytokines such as IL-1? mediated by MMP-13. Nebivolol, a licensed drug used for the treatment of hypertension in clinics, displays its anti-inflammatory capacity in various conditions. However, whether Nebivolol has a protective effect on cartilage matrix degradation has not been reported before. In this study, we investigated the effects of Nebivolol on regulating the expression of MMP-13 and degradation of type II collagen. Our results indicate that Nebivolol alleviated the increase in gene expression, protein expression, and activity of MMP-13 induced by IL-1?. Importantly, IL-1? strikingly reduced the levels of type II collagen in cell culture supernatants, which was reversed by treatment with Nebivolol in a dose-dependent manner. Mechanistically, Nebivolol was found to alleviate the increased levels of phosphorylated I?B? and reduced levels of total I?B? induced by IL-1?, which subsequently mitigated p65 nuclear translocation and the transcriptional activity of NF-?B. Furthermore, our results indicated that IL-1? treatment resulted in a significant increase in expression of the transcriptional factor interferon regulatory factor-1 (IRF-1) at both the mRNA and protein levels, which was significantly ameliorated by treatment with Nebivolol. The combination of these findings suggests that Nebivolol can potentially be applied in human OA treatment. Twit Text FOAVip Protective effects of Nebivolol against interleukin-1 (IL-1 )-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13) ????Cell Stress Chaperones http://www.kidney.de/pget.php?&tw=1&pmid=28512729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28512729 #FOAvip English Wikipedia <ref>{{Cite pmid|28512729 }}</ref> Protective effects of Nebivolol against interleukin-1? (IL-1?)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13) #MMPMID28512729 Li Z ; Liu B ; Zhao D ; Wang B ; Liu Y ; Zhang Y ; Tian F ; Li B Cell Stress Chaperones 2017[Nov]; 22 (6 ): 767-774 PMID28512729 show ga The pathological progression of osteoarthritis (OA) involves degradation of articular cartilage matrix. Type II collagen is the main component of cartilage matrix, which is degraded by pro-inflammatory cytokines such as IL-1? mediated by MMP-13. Nebivolol, a licensed drug used for the treatment of hypertension in clinics, displays its anti-inflammatory capacity in various conditions. However, whether Nebivolol has a protective effect on cartilage matrix degradation has not been reported before. In this study, we investigated the effects of Nebivolol on regulating the expression of MMP-13 and degradation of type II collagen. Our results indicate that Nebivolol alleviated the increase in gene expression, protein expression, and activity of MMP-13 induced by IL-1?. Importantly, IL-1? strikingly reduced the levels of type II collagen in cell culture supernatants, which was reversed by treatment with Nebivolol in a dose-dependent manner. Mechanistically, Nebivolol was found to alleviate the increased levels of phosphorylated I?B? and reduced levels of total I?B? induced by IL-1?, which subsequently mitigated p65 nuclear translocation and the transcriptional activity of NF-?B. Furthermore, our results indicated that IL-1? treatment resulted in a significant increase in expression of the transcriptional factor interferon regulatory factor-1 (IRF-1) at both the mRNA and protein levels, which was significantly ameliorated by treatment with Nebivolol. The combination of these findings suggests that Nebivolol can potentially be applied in human OA treatment. |Aged [MESH] |Cartilage, Articular/drug effects/metabolism [MESH] |Collagen Type II/drug effects/metabolism [MESH] |Female [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Inflammation/chemically induced/*drug therapy/genetics/pathology [MESH] |Interferon Regulatory Factor-1/*genetics [MESH] |Interleukin-1beta/administration & dosage/metabolism [MESH] |Male [MESH] |Matrix Metalloproteinase 13/*genetics [MESH] |Middle Aged [MESH] |NF-KappaB Inhibitor alpha/genetics [MESH] |NF-kappa B/genetics/metabolism [MESH] |Nebivolol/*administration & dosage [MESH] |Osteoarthritis/*drug therapy/genetics/pathology [MESH] |Proteolysis/drug effects [MESH]Protective effects of Nebivolol against interleukin-1? (IL-1?)-induced(epmc).pdf DeepDyve Pubget Overpricing