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2017 ; 8
(46
): 80700-80708
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Long noncoding RNA SNHG20 promotes gastric cancer progression by inhibiting p21
expression and regulating the GSK-3?/ ?-catenin signaling pathway
#MMPMID29113337
Liu J
; Liu L
; Wan JX
; Song Y
Oncotarget
2017[Oct]; 8
(46
): 80700-80708
PMID29113337
show ga
Recent studies have indicated that long non-coding RNAs (lncRNAs) play important
regulatory roles in tumor development and progression. However, the contribution
of small nucleolar RNA host gene 20 (SNHG20) to gastric cancer development
remains largely unknown. The aim of the study is to investigate the functional
significance of SNHG20 involved in gastric cancer (GC) progression. In the study,
our results demonstrated that the expression levels of SNHG20 were remarkably
up-regulated in GC cells. Functionally, SNHG20 promoted the GC MKN45 and BGC-823
cells proliferation and invasion. Furthermore, knockdown of SNHG20 significantly
inhibited the epithelial-mesenchymal transition (EMT) in MKN45 and BGC-823 cells,
whereas, the overexpression of SNHG20 had the promoting effects. Moreover, we
found that overexpression of SNHG20 in MKN45 and BGC-823 cells significantly
inhibited the expression of E-cadherin and p21 via binding to EZH2 and regulated
the GSK-3?/?-catenin signaling pathway. Thus, the results showed that SNHG20
acted as an oncogene in GC and targeting SNHG20 may serve as a therapeutic target
for GC.