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10.18632/oncotarget.18170 http://scihub22266oqcxt.onion/10.18632/oncotarget.18170 C5655201!5655201!29113306     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (46): 80325-35 Nephropedia Template TP {{tp|p=29113306|t=2017. Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis |pdf=|usr=}}{{29113306}} gab.com Text Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29113306 #FOAvip Colorectal cancer (CRC) is one of the most dangerous types of malignant tumors, and cancer metastasis is a major factor in the failure of CRC therapy. Recently, LOXL2 (lysyl oxidase-like 2) has been shown to represent a regulator of epithelial-mesenchymal transition (EMT) in different cancer types. However, LOXL2 has not been reported to be involved in CRC metastasis. In this study, we demonstrated that LOXL2 expression is strongly correlated with the rate of CRC metastasis, it participates in the regulation of EMT-related molecule expression in CRC cells in vitro, and it is involved in migratory potential alterations. Additionally, tissue microarray analysis of CRC patients showed an increase in the probability of developing CRC distant metastasis and a decrease in the survival rate of patients with high LOXL2 expression. The results obtained in this study indicate that LOXL2 is involved in the development and progression of CRC metastasis, and therefore, its expression levels may represent a useful prognostic marker. Twit Text FOAVip Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29113306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29113306 #FOAvip English Wikipedia <ref>{{Cite pmid|29113306}}</ref> Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis #MMPMID29113306 Park PG; Jo SJ; Kim MJ; Kim HJ; Lee JH; Park CK; Kim H; Lee KY; Kim H; Park JH; Dong SM; Lee JM Oncotarget 2017[Oct]; 8 (46): 80325-35 PMID29113306show ga Colorectal cancer (CRC) is one of the most dangerous types of malignant tumors, and cancer metastasis is a major factor in the failure of CRC therapy. Recently, LOXL2 (lysyl oxidase-like 2) has been shown to represent a regulator of epithelial-mesenchymal transition (EMT) in different cancer types. However, LOXL2 has not been reported to be involved in CRC metastasis. In this study, we demonstrated that LOXL2 expression is strongly correlated with the rate of CRC metastasis, it participates in the regulation of EMT-related molecule expression in CRC cells in vitro, and it is involved in migratory potential alterations. Additionally, tissue microarray analysis of CRC patients showed an increase in the probability of developing CRC distant metastasis and a decrease in the survival rate of patients with high LOXL2 expression. The results obtained in this study indicate that LOXL2 is involved in the development and progression of CRC metastasis, and therefore, its expression levels may represent a useful prognostic marker. äRole of LOXL2 in the epithelial-mesenchymal transition and colorectal (epmc).pdf DeepDyve Pubget Overpricing