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10.18632/oncotarget.21261 http://scihub22266oqcxt.onion/10.18632/oncotarget.21261 C5655187!5655187!29113292     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29113292&cmd=llinks): Failed to open stream: HTTP request failed! 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NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer |pdf=|usr=}}{{29113292}} gab.com Text NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29113292 #FOAvip Pancreatic cancer is a high mortality form of cancer, with a median survival only six months. There are multiple associated risk factors associated, most importantly type 2 diabetes, obesity, pancreatitis and smoking. The relative rarity of the disease, however, has made it difficult to dissect causative risk factors, especially with related risk factors. A major unanswered question with important therapeutic implications is the effect of immunological responses on pancreatic cancer formation, with data from other cancers suggesting the potential for local immunological responses to either increase cancer development or increase cancer elimination. Due to the rarity and late diagnosis of pancreatic cancer direct epidemiological evidence is lacking, thus necessitating a reliance on animal models. Here we investigated the relationship between pancreatic autoimmunity and cancer by backcrossing the well characterised Ela1-Tag transgenic model of pancreatic cancer onto the pancreatic autoimmune susceptible NOD mouse strain. Through longitudinal magnetic resonance imaging we found that the NOD genetic background delayed the onset of pancreatic tumours and substantially slowed the growth rate of tumours after development. These results suggest that elevated autoimmune surveillance of the pancreas limits tumour formation and growth, identifying pancreatic cancer as a promising target for immune checkpoint blockade therapies that unleash latent autoimmunity. Twit Text FOAVip NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29113292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29113292 #FOAvip English Wikipedia <ref>{{Cite pmid|29113292}}</ref> NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer #MMPMID29113292 Dooley J; Pasciuto E; Lagou V; Lampi Y; Dresselaers T; Himmelreich U; Liston A Oncotarget 2017[Oct]; 8 (46): 80167-74 PMID29113292show ga Pancreatic cancer is a high mortality form of cancer, with a median survival only six months. There are multiple associated risk factors associated, most importantly type 2 diabetes, obesity, pancreatitis and smoking. The relative rarity of the disease, however, has made it difficult to dissect causative risk factors, especially with related risk factors. A major unanswered question with important therapeutic implications is the effect of immunological responses on pancreatic cancer formation, with data from other cancers suggesting the potential for local immunological responses to either increase cancer development or increase cancer elimination. Due to the rarity and late diagnosis of pancreatic cancer direct epidemiological evidence is lacking, thus necessitating a reliance on animal models. Here we investigated the relationship between pancreatic autoimmunity and cancer by backcrossing the well characterised Ela1-Tag transgenic model of pancreatic cancer onto the pancreatic autoimmune susceptible NOD mouse strain. Through longitudinal magnetic resonance imaging we found that the NOD genetic background delayed the onset of pancreatic tumours and substantially slowed the growth rate of tumours after development. These results suggest that elevated autoimmune surveillance of the pancreas limits tumour formation and growth, identifying pancreatic cancer as a promising target for immune checkpoint blockade therapies that unleash latent autoimmunity. äNOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed (epmc).pdf DeepDyve Pubget Overpricing