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10.1128/AAC.01367-17

http://scihub22266oqcxt.onion/10.1128/AAC.01367-17
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C5655114!5655114!28893780
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suck abstract from ncbi


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pmid28893780      Antimicrob+Agents+Chemother 2017 ; 61 (11): ä
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  • Pharmacokinetic/Toxicodynamic Analysis of Colistin-Associated Acute Kidney Injury in Critically Ill Patients #MMPMID28893780
  • Forrest A; Garonzik SM; Thamlikitkul V; Giamarellos-Bourboulis EJ; Paterson DL; Li J; Silveira FP; Nation RL
  • Antimicrob Agents Chemother 2017[Nov]; 61 (11): ä PMID28893780show ga
  • Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ?2 mg/liter.
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