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10.1016/j.jdiacomp.2017.01.013 http://scihub22266oqcxt.onion/10.1016/j.jdiacomp.2017.01.013 C5654524!5654524!28190681     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28190681&cmd=llinks): Failed to open stream: HTTP request failed! 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Differential effects of metformin on age related comorbidities in older men with type 2 diabetes |pdf=|usr=}}{{28190681}} gab.com Text Differential effects of metformin on age related comorbidities in older men with type 2 diabetes JO: J Diabetes Complications http://www.kidney.de/pget.php?&tw=1&pmid=28190681 #FOAvip Aims: To identify distinct temporal likelihoods of age-related comorbidity (ARC) diagnoses: cardiovascular diseases (CVD), cancer, depression, dementia, and frailty-related diseases (FRD) in older men with type 2 diabetes (T2D) but ARC naïve initially, and assess the heterogeneous effects of metformin on ARCs and mortality. Methods: We identified a clinical cohort of male veterans in the United States who were ? 65 years old with T2D and free from ARCs during 2002?2003. ARC diagnoses during 2004?2012 were analyzed using latent class modeling adjusted for confounders. Results: The cohort consisted of 41,204 T2D men with age 74.6 ± 5.8 years, HbA1c 6.5 ± 0.97%, and 8393 (20.4%) metformin users. Four ARC classes were identified. ?Healthy Class? (53.6%): metformin reduced likelihoods of all ARCs (from 0.14% in dementia to 6.1% in CVD). ?High Cancer Risk Class? (11.6%): metformin reduced likelihoods of CVD (13.3%), cancer (45.5%), depression (5.0%), and FRD (13.7%). ?High CVD Risk Class? (17.4%): metformin reduced likelihoods of CVD (48.6%), cancer (3.2%), depression (2.8%), and FRD (6.3%). ?High Frailty Risk Class? (17.2%): metformin reduced likelihoods of CVD (18.8%), cancer (3.9%), dementia (3.8%), depression (15.6%), and FRD (23.8%). Conclusions: Metformin slowed ARC development in old men with T2D, and these effects varied by ARC phenotype. Twit Text FOAVip Differential effects of metformin on age related comorbidities in older men with type 2 diabetes ????J Diabetes Complications http://www.kidney.de/pget.php?&tw=1&pmid=28190681 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28190681 #FOAvip English Wikipedia <ref>{{Cite pmid|28190681}}</ref> Differential effects of metformin on age related comorbidities in older men with type 2 diabetes #MMPMID28190681 Wang CP; Lorenzo C; Habib SL; Jo B; Espinoza SE J Diabetes Complications 2017[Apr]; 31 (4): 679-86 PMID28190681show ga Aims: To identify distinct temporal likelihoods of age-related comorbidity (ARC) diagnoses: cardiovascular diseases (CVD), cancer, depression, dementia, and frailty-related diseases (FRD) in older men with type 2 diabetes (T2D) but ARC naïve initially, and assess the heterogeneous effects of metformin on ARCs and mortality. Methods: We identified a clinical cohort of male veterans in the United States who were ? 65 years old with T2D and free from ARCs during 2002?2003. ARC diagnoses during 2004?2012 were analyzed using latent class modeling adjusted for confounders. Results: The cohort consisted of 41,204 T2D men with age 74.6 ± 5.8 years, HbA1c 6.5 ± 0.97%, and 8393 (20.4%) metformin users. Four ARC classes were identified. ?Healthy Class? (53.6%): metformin reduced likelihoods of all ARCs (from 0.14% in dementia to 6.1% in CVD). ?High Cancer Risk Class? (11.6%): metformin reduced likelihoods of CVD (13.3%), cancer (45.5%), depression (5.0%), and FRD (13.7%). ?High CVD Risk Class? (17.4%): metformin reduced likelihoods of CVD (48.6%), cancer (3.2%), depression (2.8%), and FRD (6.3%). ?High Frailty Risk Class? (17.2%): metformin reduced likelihoods of CVD (18.8%), cancer (3.9%), dementia (3.8%), depression (15.6%), and FRD (23.8%). Conclusions: Metformin slowed ARC development in old men with T2D, and these effects varied by ARC phenotype. äDifferential effects of metformin on age related comorbidities in olde(epmc).pdf DeepDyve Pubget Overpricing