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10.1038/s41598-017-13739-9 http://scihub22266oqcxt.onion/10.1038/s41598-017-13739-9 C5653802!5653802!29061990     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29061990|t=2017. TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function |pdf=|usr=}}{{29061990}} gab.com Text TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29061990 #FOAvip Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND participants to examine associations of plasma TMAO with all-cause mortality. After median follow-up of 8.3 years in 5,469 participants, 322 subjects died. TMAO was positively associated with age, body mass index, type 2 diabetes mellitus and inversely with estimated glomerular filtration rate (eGFRcreatcysC)(all P?<?0.001). Subjects in the highest versus lowest TMAO quartile had a crude 1.86-fold higher mortality risk (Ptrend?<?0.001). After adjustment for several risk factors, TMAO remained associated with all-cause mortality [HR:1.36 (95% CI, 0.97?1.91),Ptrend?=?0.016]. This association was lost after further adjustment for urinary albumin excretion and eGFR [HR:1.15 (95% CI, 0.81?1.64),Ptrend?=?0.22]. The association of TMAO with mortality was modified by eGFR in crude and age- and sex-adjusted analyses (interaction P?=?0.002). When participants were stratified by renal function (eGFR < vs. ?90?mL/min/1.73?m2), TMAO was associated with all-cause mortality only in subjects with eGFR <90?mL/min/1.73?m2 [adjusted HR:1.18 (95% CI, 1.02?1.36),P?=?0.023]. In conclusion, TMAO is associated with all-cause mortality, particularly in subjects with eGFR <90?mL/min/1.73?m2. Twit Text FOAVip TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29061990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29061990 #FOAvip English Wikipedia <ref>{{Cite pmid|29061990}}</ref> TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function #MMPMID29061990 Gruppen EG; Garcia E; Connelly MA; Jeyarajah EJ; Otvos JD; Bakker SJL; Dullaart RPF Sci Rep 2017[]; 7 (ä): ä PMID29061990show ga Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND participants to examine associations of plasma TMAO with all-cause mortality. After median follow-up of 8.3 years in 5,469 participants, 322 subjects died. TMAO was positively associated with age, body mass index, type 2 diabetes mellitus and inversely with estimated glomerular filtration rate (eGFRcreatcysC)(all P? äTMAO is Associated with Mortality: Impact of Modestly Impaired Renal F(epmc).pdf DeepDyve Pubget Overpricing