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10.1016/j.molimm.2007.09.018 http://scihub22266oqcxt.onion/10.1016/j.molimm.2007.09.018 C5653245!5653245!18006061     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Immunol 2008 ; 45 (5): 1288-97 Nephropedia Template TP {{tp|p=18006061|t=2008. Cloning, expression and characterization of ferret CXCL10 |pdf=|usr=}}{{18006061}} gab.com Text Cloning, expression and characterization of ferret CXCL10 JO: Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18006061 #FOAvip Chemokines and their receptors function in the recruitment and activation of cells of the immune system to sites of inflammation. As such, chemokines play an important role in mediating pathophysiological events during microbial infection. In particular, CXCL9, CXCL10 and CXCL11 and their cognate receptor CXCR3 have been associated with the clinical course of several infectious diseases, including severe acute respiratory syndrome (SARS) and influenza. While CXCL9, CXCL10 and CXCL11 share the same receptor and have overlapping functions, each can also have unique activity in host defense. The lack of a preferred characterized animal model for SARS has brought our attention to ferrets, which have been used for years in influenza studies. The lack of immunological reagents for ferrets prompted us to clone CXCL9, CXCL10, CXCL11 and CXCR3 and, in the case of CXCL10, to express the gene as a recombinant protein. In this study we demonstrate that endogenous ferret CXCL10 exhibits similar mRNA expression patterns in the lungs of deceased SARS patients and ferrets experimentally infected with SARS coronavirus. This study therefore represents an important step towards development of the ferret as a model for the role of CXCL9, CXCL10 and CXCL11:CXCR3 axis in severe viral infections. Twit Text FOAVip Cloning, expression and characterization of ferret CXCL10 ????Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18006061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18006061 #FOAvip English Wikipedia <ref>{{Cite pmid|18006061}}</ref> Cloning, expression and characterization of ferret CXCL10 #MMPMID18006061 Danesh A; Seneviratne C; Cameron CM; Banner D; Devries ME; Kelvin AA; Xu L; Ran L; Bosinger SE; Rowe T; Czub M; Jonsson CB; Cameron MJ; Kelvin DJ Mol Immunol 2008[Mar]; 45 (5): 1288-97 PMID18006061show ga Chemokines and their receptors function in the recruitment and activation of cells of the immune system to sites of inflammation. As such, chemokines play an important role in mediating pathophysiological events during microbial infection. In particular, CXCL9, CXCL10 and CXCL11 and their cognate receptor CXCR3 have been associated with the clinical course of several infectious diseases, including severe acute respiratory syndrome (SARS) and influenza. While CXCL9, CXCL10 and CXCL11 share the same receptor and have overlapping functions, each can also have unique activity in host defense. The lack of a preferred characterized animal model for SARS has brought our attention to ferrets, which have been used for years in influenza studies. The lack of immunological reagents for ferrets prompted us to clone CXCL9, CXCL10, CXCL11 and CXCR3 and, in the case of CXCL10, to express the gene as a recombinant protein. In this study we demonstrate that endogenous ferret CXCL10 exhibits similar mRNA expression patterns in the lungs of deceased SARS patients and ferrets experimentally infected with SARS coronavirus. This study therefore represents an important step towards development of the ferret as a model for the role of CXCL9, CXCL10 and CXCL11:CXCR3 axis in severe viral infections. äCloning, expression and characterization of ferret CXCL10 (epmc).pdf DeepDyve Pubget Overpricing