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2017 ; 38
(4
): 1967-1976
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gab.com Text
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TRPM7 is overexpressed in bladder cancer and promotes proliferation, migration,
invasion and tumor growth
#MMPMID28791418
Gao SL
; Kong CZ
; Zhang Z
; Li ZL
; Bi JB
; Liu XK
Oncol Rep
2017[Oct]; 38
(4
): 1967-1976
PMID28791418
show ga
Recent findings suggest that the melastatin transient receptor potential
channel 7 (TRPM7) is overexpressed in many types of cancers and is involved in
tumorigenesis. However, its expression pattern and the potential role in bladder
cancer remain unclear. The aim of the present study was to investigate the
expression status of TRPM7 and its relationship with the development of bladder
cancer. In the present study, we observed that the expression of TRPM7 was
significantly elevated in bladder cancer tissues compared with that noted in the
adjacent non-tumor tissues. Furthermore, increased TRPM7 expression was
significantly associated with recurrence, metastasis and prognosis. In addition,
after knockdown of the expression of TRPM7 by siRNA, the proliferation and the
motility of T24 and 5637 cells were obviously inhibited, and downregulation of
TRPM7 was found to play an important role in bladder cancer cell apoptosis. In
conclusion, our findings suggest that TRPM7 plays an important role in bladder
cancer, and TRPM7 may serve as a potentially unfavorable factor and novel target
for human bladder cancer.
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