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2017 ; 8
(44
): 77999-78010
Nephropedia Template TP
gab.com Text
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English Wikipedia
Evaluating the prognostic value of miR-148/152 family in cancers: based on a
systemic review of observational studies
#MMPMID29100442
Duan F
; Liu W
; Fu X
; Feng Y
; Dai L
; Cui S
; Yang Z
Oncotarget
2017[Sep]; 8
(44
): 77999-78010
PMID29100442
show ga
BACKGROUND: The prognostic significance of MicroRNA-148/152 (miR-148/152) family
expression in various cancers has been investigated by many studies with
inconsistent results. To address this issue, we performed a meta-analysis to
clarify this relationship. MATERIALS AND METHODS: Eligible studies were recruited
by a systematic literature search and assessed the quality of included studies
based on Quality In Prognosis Studies (QUIPS) and Newcastle-Ottawa Scale (NOS).
Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for overall
survival (OS) and disease free survival/progressive free survival/recurrence free
survival (DFS/PFS/RFS) were calculated to estimate the effects of miR-148/152
family expression on prognosis. RESULTS: A final total of 23 articles (26
studies) were considered in evidence synthesis. A significant association was
observed between low miR-148a level and poor OS in patients (HR = 1.59, 95% CI:
1.14 - 2.20, P = 0.00), especially with digestive tract cancer (DTC) (HR = 1.29,
95% CI: 1.03-1.63, P = 0.03), and another significant association was observed
between low miR-148b level and poor OS in patients (HR=2.09, 95% CI: 1.70-2.56, P
= 0.00), especially with (hepatocellular carcinoma) HCC (HR = 1.97, 95% Cl:
1.52-2.56, P = 0.00) and non-small cell lung cancer (NSCLC) (HR = 2.29, 95% Cl:
1.64-3.18, P = 0.00). The significant correlation between miR-152 and DFS/RFS was
found in our research (HR = 3.49, 95% Cl: 1.13-10.08, P = 0.03). CONCLUSIONS: Our
findings suggest that low miR-148/152 family expression is significantly
associated with poor prognosis and may be a feasible prognostic biomarker in some
cancers, especially in HCC and NSCLC.