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10.18632/oncotarget.20805 http://scihub22266oqcxt.onion/10.18632/oncotarget.20805 C5652735!5652735!29100341     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (44): 76686-98 Nephropedia Template TP {{tp|p=29100341|t=2017. Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells |pdf=|usr=}}{{29100341}} gab.com Text Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29100341 #FOAvip Microtentacles are mostly microtubule-based cell protrusions that are formed by detached tumor cells. Here, we report that the formation of tumor cell microtentacles depends on the presence and dynamics of guanine nucleotide-binding proteins of the septin family, which are part of the cytoskeleton. In matrix-attached breast, lung, prostate and pancreas cancer cells, septins are associated with the cytosolic actin cytoskeleton. Detachment of cells causes redistribution of septins to the membrane, where microtentacle formation occurs. Forchlorfenuron, which inhibits septin functions, blocks microtentacle formation. The small GTPase Cdc42 and its effector proteins Borgs regulate septins and are essential for microtentacle formation. Dominant active and inactive Cdc42 inhibit microtentacle formation indicating that the free cycling of Cdc42 between its active and inactive state is essential for septin regulation and microtentacle formation. Cell attachment and aggregation models suggest that septins play an essential role in the metastatic behavior of tumor cells. Twit Text FOAVip Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29100341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29100341 #FOAvip English Wikipedia <ref>{{Cite pmid|29100341}}</ref> Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells #MMPMID29100341 Østevold K; Meléndez AV; Lehmann F; Schmidt G; Aktories K; Schwan C Oncotarget 2017[Sep]; 8 (44): 76686-98 PMID29100341show ga Microtentacles are mostly microtubule-based cell protrusions that are formed by detached tumor cells. Here, we report that the formation of tumor cell microtentacles depends on the presence and dynamics of guanine nucleotide-binding proteins of the septin family, which are part of the cytoskeleton. In matrix-attached breast, lung, prostate and pancreas cancer cells, septins are associated with the cytosolic actin cytoskeleton. Detachment of cells causes redistribution of septins to the membrane, where microtentacle formation occurs. Forchlorfenuron, which inhibits septin functions, blocks microtentacle formation. The small GTPase Cdc42 and its effector proteins Borgs regulate septins and are essential for microtentacle formation. Dominant active and inactive Cdc42 inhibit microtentacle formation indicating that the free cycling of Cdc42 between its active and inactive state is essential for septin regulation and microtentacle formation. Cell attachment and aggregation models suggest that septins play an essential role in the metastatic behavior of tumor cells. äSeptin remodeling is essential for the formation of cell membrane prot(epmc).pdf DeepDyve Pubget Overpricing