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10.18632/oncotarget.19346 http://scihub22266oqcxt.onion/10.18632/oncotarget.19346 C5652704!5652704!29100310     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (44): 76266-78 Nephropedia Template TP {{tp|p=29100310|t=2017. Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/?-catenin signaling pathway |pdf=|usr=}}{{29100310}} gab.com Text Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/ -catenin signaling pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29100310 #FOAvip Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic pyrophosphate levels, and its expression is correlated with growth of several solid tumors. To investigate this relationship, we first examined PPA1 expression in human epithelial ovarian cancer (EOC) samples, and found that PPA1 was overexpressed in tumors from EOC patients. Higher PPA1 levels correlated with advanced grades, stages, and poor survival in EOC patients. Examination of PPA1 function in EOC revealed that silencing PPA1 inhibited EOC migration, epithelial-mesenchymal transition (EMT), and metastasis in vitro and in vivo. In addition, PPA1 may promote the dephosphorylation and translocation of ?-catenin. These results demonstrate that silencing PPA1 inhibits EOC metastasis by suppressing the Wnt/?-catenin signaling pathway. Strategies for downregulating PPA1 may have therapeutic potential for the prevention and treatment of EOC. Twit Text FOAVip Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/ -catenin signaling pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29100310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29100310 #FOAvip English Wikipedia <ref>{{Cite pmid|29100310}}</ref> Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/?-catenin signaling pathway #MMPMID29100310 Niu H; Zhou W; Xu Y; Yin Z; Shen W; Ye Z; Liu Y; Chen Y; Yang S; Xiang R; Wang L; Qu P Oncotarget 2017[Sep]; 8 (44): 76266-78 PMID29100310show ga Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic pyrophosphate levels, and its expression is correlated with growth of several solid tumors. To investigate this relationship, we first examined PPA1 expression in human epithelial ovarian cancer (EOC) samples, and found that PPA1 was overexpressed in tumors from EOC patients. Higher PPA1 levels correlated with advanced grades, stages, and poor survival in EOC patients. Examination of PPA1 function in EOC revealed that silencing PPA1 inhibited EOC migration, epithelial-mesenchymal transition (EMT), and metastasis in vitro and in vivo. In addition, PPA1 may promote the dephosphorylation and translocation of ?-catenin. These results demonstrate that silencing PPA1 inhibits EOC metastasis by suppressing the Wnt/?-catenin signaling pathway. Strategies for downregulating PPA1 may have therapeutic potential for the prevention and treatment of EOC. äSilencing PPA1 inhibits human epithelial ovarian cancer metastasis by (epmc).pdf DeepDyve Pubget Overpricing