Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing
the Wnt/?-catenin signaling pathway
#MMPMID29100310
Niu H
; Zhou W
; Xu Y
; Yin Z
; Shen W
; Ye Z
; Liu Y
; Chen Y
; Yang S
; Xiang R
; Wang L
; Qu P
Oncotarget
2017[Sep]; 8
(44
): 76266-76278
PMID29100310
show ga
Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular
inorganic pyrophosphate levels, and its expression is correlated with growth of
several solid tumors. To investigate this relationship, we first examined PPA1
expression in human epithelial ovarian cancer (EOC) samples, and found that PPA1
was overexpressed in tumors from EOC patients. Higher PPA1 levels correlated with
advanced grades, stages, and poor survival in EOC patients. Examination of PPA1
function in EOC revealed that silencing PPA1 inhibited EOC migration,
epithelial-mesenchymal transition (EMT), and metastasis in vitro and in vivo. In
addition, PPA1 may promote the dephosphorylation and translocation of ?-catenin.
These results demonstrate that silencing PPA1 inhibits EOC metastasis by
suppressing the Wnt/?-catenin signaling pathway. Strategies for downregulating
PPA1 may have therapeutic potential for the prevention and treatment of EOC.
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