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10.3389/fphar.2017.00749 http://scihub22266oqcxt.onion/10.3389/fphar.2017.00749 C5651268!5651268 !29093682     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29093682 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Pharmacol 2017 ; 8 (ä): 749 Nephropedia Template TP {{tp|p=29093682 |t=2017. Salidroside, A Natural Antioxidant, Improves ?-Cell Survival and Function via Activating AMPK Pathway |pdf=|usr=}}{{29093682 }} gab.com Text Salidroside, A Natural Antioxidant, Improves -Cell Survival and Function via Activating AMPK Pathway JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=29093682 #FOAvip Aim: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus (T2DM) and induces ?-cell failure. Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. This study was aimed to evaluate protective effects of salidroside on ?-cells against diabetes associated oxidative stress. Methods and Results: In diabetic db/db and high-fat diet-induced mice, we found salidroside ameliorated hyperglycemia and relieved oxidative stress. More importantly, salidroside increased ?-cell mass and ?-cell replication of diabetic mice. Mechanism study in Min6 cells revealed that, under diabetic stimuli, salidroside suppressed reactive oxygen species production and restore mitochondrial membrane potential (??m) via reducing NOX2 expression and inhibiting JNK-caspase 3 apoptotic cascade subsequently to protect ?-cell survival. Simultaneously, diabetes associated oxidative stress also activated FOXO1 and triggered nuclear exclusion of PDX1 which resulted in ?-cell dysfunction. This deleterious result was reversed by salidroside by activating AMPK-AKT to inhibit FOXO1 and recover PDX1 nuclear localization. The efficacy of salidroside in improving ?-cell survival and function was further confirmed in isolated cultured mouse islets. Moreover, the protective effects of salidroside on ?-cells against diabetic stimuli can be abolished by an AMPK inhibitor compound C, which indicated functions of salidroside on ?-cells were AMPK activation dependent. Conclusion: These results confirmed beneficial metabolic effects of salidroside and identified a novel role for salidroside in preventing ?-cell failure via AMPK activation. Our finding highlights the potential value of Rhodiola rosea as a dietary supplement for diabetes control. Twit Text FOAVip Salidroside, A Natural Antioxidant, Improves -Cell Survival and Function via Activating AMPK Pathway ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=29093682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29093682 #FOAvip English Wikipedia <ref>{{Cite pmid|29093682 }}</ref> Salidroside, A Natural Antioxidant, Improves ?-Cell Survival and Function via Activating AMPK Pathway #MMPMID29093682 Ju L ; Wen X ; Wang C ; Wei Y ; Peng Y ; Ding Y ; Feng L ; Shu L Front Pharmacol 2017[]; 8 (ä): 749 PMID29093682 show ga Aim: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus (T2DM) and induces ?-cell failure. Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. This study was aimed to evaluate protective effects of salidroside on ?-cells against diabetes associated oxidative stress. Methods and Results: In diabetic db/db and high-fat diet-induced mice, we found salidroside ameliorated hyperglycemia and relieved oxidative stress. More importantly, salidroside increased ?-cell mass and ?-cell replication of diabetic mice. Mechanism study in Min6 cells revealed that, under diabetic stimuli, salidroside suppressed reactive oxygen species production and restore mitochondrial membrane potential (??m) via reducing NOX2 expression and inhibiting JNK-caspase 3 apoptotic cascade subsequently to protect ?-cell survival. Simultaneously, diabetes associated oxidative stress also activated FOXO1 and triggered nuclear exclusion of PDX1 which resulted in ?-cell dysfunction. This deleterious result was reversed by salidroside by activating AMPK-AKT to inhibit FOXO1 and recover PDX1 nuclear localization. The efficacy of salidroside in improving ?-cell survival and function was further confirmed in isolated cultured mouse islets. Moreover, the protective effects of salidroside on ?-cells against diabetic stimuli can be abolished by an AMPK inhibitor compound C, which indicated functions of salidroside on ?-cells were AMPK activation dependent. Conclusion: These results confirmed beneficial metabolic effects of salidroside and identified a novel role for salidroside in preventing ?-cell failure via AMPK activation. Our finding highlights the potential value of Rhodiola rosea as a dietary supplement for diabetes control. äSalidroside, A Natural Antioxidant, Improves ?-Cell Survival and Funct(epmc).pdf DeepDyve Pubget Overpricing