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10.1038/nchem.2706 http://scihub22266oqcxt.onion/10.1038/nchem.2706 C5648535!5648535 !28644464     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28644464 &cmd=llinks): Failed to open stream: HTTP request failed! 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A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations |pdf=|usr=}}{{28644464 }} gab.com Text A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations JO: Nat Chem http://www.kidney.de/pget.php?&tw=1&pmid=28644464 #FOAvip Perturbations in cellular chloride concentrations can affect cellular pH and autophagy and lead to the onset of apoptosis. With this in mind, synthetic ion transporters have been used to disturb cellular ion homeostasis and thereby induce cell death; however, it is not clear whether synthetic ion transporters can also be used to disrupt autophagy. Here, we show that squaramide-based ion transporters enhance the transport of chloride anions in liposomal models and promote sodium chloride influx into the cytosol. Liposomal and cellular transport activity of the squaramides is shown to correlate with cell death activity, which is attributed to caspase-dependent apoptosis. One ion transporter was also shown to cause additional changes in lysosomal pH, which leads to impairment of lysosomal enzyme activity and disruption of autophagic processes. This disruption is independent of the initiation of apoptosis by the ion transporter. This study provides the first experimental evidence that synthetic ion transporters can disrupt both autophagy and induce apoptosis. Twit Text FOAVip A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations ????Nat Chem http://www.kidney.de/pget.php?&tw=1&pmid=28644464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28644464 #FOAvip English Wikipedia <ref>{{Cite pmid|28644464 }}</ref> A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations #MMPMID28644464 Busschaert N ; Park SH ; Baek KH ; Choi YP ; Park J ; Howe ENW ; Hiscock JR ; Karagiannidis LE ; Marques I ; Félix V ; Namkung W ; Sessler JL ; Gale PA ; Shin I Nat Chem 2017[Jul]; 9 (7 ): 667-675 PMID28644464 show ga Perturbations in cellular chloride concentrations can affect cellular pH and autophagy and lead to the onset of apoptosis. With this in mind, synthetic ion transporters have been used to disturb cellular ion homeostasis and thereby induce cell death; however, it is not clear whether synthetic ion transporters can also be used to disrupt autophagy. Here, we show that squaramide-based ion transporters enhance the transport of chloride anions in liposomal models and promote sodium chloride influx into the cytosol. Liposomal and cellular transport activity of the squaramides is shown to correlate with cell death activity, which is attributed to caspase-dependent apoptosis. One ion transporter was also shown to cause additional changes in lysosomal pH, which leads to impairment of lysosomal enzyme activity and disruption of autophagic processes. This disruption is independent of the initiation of apoptosis by the ion transporter. This study provides the first experimental evidence that synthetic ion transporters can disrupt both autophagy and induce apoptosis. |Apoptosis/*drug effects [MESH] |Autophagy/*drug effects [MESH] |Chlorides/chemistry/*pharmacology [MESH] |Dose-Response Relationship, Drug [MESH] |HeLa Cells [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Ion Transport/drug effects [MESH] |Molecular Structure [MESH] |Quinine/*analogs & derivatives/chemistry/pharmacology [MESH]A synthetic ion transporter that disrupts autophagy and induces apopto(epmc).pdf DeepDyve Pubget Overpricing