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10.1097/ACI.0000000000000338 http://scihub22266oqcxt.onion/10.1097/ACI.0000000000000338 C5647651!5647651!28030377     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28030377&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Allergy+Clin+Immunol 2017 ; 17 (2): 116-22 Nephropedia Template TP {{tp|p=28030377|t=2017. Microbes, Allergic Sensitization and the Natural History of Asthma |pdf=|usr=}}{{28030377}} gab.com Text Microbes, Allergic Sensitization and the Natural History of Asthma JO: Curr Opin Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28030377 #FOAvip Purpose of review: Understanding factors that lead to asthma development in early life is essential to developing strategies aimed at primary or secondary prevention. Recent findings: This article will review current evidence addressing the development of early life allergic sensitization in relation to microbes and the gut and airway microbiome. Wheezing illnesses, particularly viral, remain a significant risk factor for asthma inception; however, bacterial pathogens have recently emerged as an additional important contributor to asthma risk, either alone or as cofactors with viral infections. The combined influence and interaction of early life viral wheezing and aeroallergen sensitization is important, with allergic sensitization preceeding the onset of viral wheeze. Lastly, we review recent data from longitudinal studies regarding the development of irreversible airway obstruction and its impact on the natural history of asthma. Summary: The development of asthma remains complex and incompletely understood. There is interplay between genetic predisposition and environmental exposures, including allergens and microbes. Interventions aimed at these risk factors during the preschool years may prevent the longitudinal course of asthma progression to irreversible airway obstruction. Twit Text FOAVip Microbes, Allergic Sensitization and the Natural History of Asthma ????Curr Opin Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28030377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28030377 #FOAvip English Wikipedia <ref>{{Cite pmid|28030377}}</ref> Microbes, Allergic Sensitization and the Natural History of Asthma #MMPMID28030377 Anderson HM; Jackson DJ Curr Opin Allergy Clin Immunol 2017[Apr]; 17 (2): 116-22 PMID28030377show ga Purpose of review: Understanding factors that lead to asthma development in early life is essential to developing strategies aimed at primary or secondary prevention. Recent findings: This article will review current evidence addressing the development of early life allergic sensitization in relation to microbes and the gut and airway microbiome. Wheezing illnesses, particularly viral, remain a significant risk factor for asthma inception; however, bacterial pathogens have recently emerged as an additional important contributor to asthma risk, either alone or as cofactors with viral infections. The combined influence and interaction of early life viral wheezing and aeroallergen sensitization is important, with allergic sensitization preceeding the onset of viral wheeze. Lastly, we review recent data from longitudinal studies regarding the development of irreversible airway obstruction and its impact on the natural history of asthma. Summary: The development of asthma remains complex and incompletely understood. There is interplay between genetic predisposition and environmental exposures, including allergens and microbes. Interventions aimed at these risk factors during the preschool years may prevent the longitudinal course of asthma progression to irreversible airway obstruction. äMicrobes, Allergic Sensitization and the Natural History of Asthma (epmc).pdf DeepDyve Pubget Overpricing