Trends Cancer 2017[Jul]; 3 (7): 471-4 PMID28718401show ga
Expression of activating transcription factor 5 (ATF5) negatively correlates with patient survival for different types of cancers. Here, we illustrate ATF5 is important for survival and proliferation of cancer and can be targeted to selectively trigger apoptosis of cancer cells, but sparing normal cells. Cell-penetrating peptides combined with a dominant negative ATF5 cargo have shown efficacy in brain, breast, melanoma, and prostate cancers.