Mitophagy, metabolism, and cell fate #MMPMID29057310
Esteban-Martínez L; Sierra-Filardi E; Boya P
Mol Cell Oncol 2017[]; 4 (5): ä PMID29057310show ga
Mitophagy is the process by which cells eliminate damaged or superfluous mitochondria by degrading them within lysosomes. We show that during development, selective removal of mitochondria by autophagy induces a metabolic shift toward glycolysis that is essential for differentiation of several cell types. These findings suggest potential applications of cell-fate manipulation strategies targeting mitophagy.