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10.1073/pnas.1707364114 http://scihub22266oqcxt.onion/10.1073/pnas.1707364114 C5642699!5642699!28973891     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (41): 10948-53 Nephropedia Template TP {{tp|p=28973891|t=2017. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4 |pdf=|usr=}}{{28973891}} gab.com Text Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28973891 #FOAvip How C4a transduces signaling and generates various biological functions has long been unresolved. Using a cell-based reporter assay, we screened C4a against a panel of 168 known and 73 orphan G protein-coupled receptors and now provide evidence that C4a is a ligand for protease-activated receptor (PAR)1 and PAR4. In human endothelial cells, our assessment of ERK activation and calcium mobilization in the presence of various antagonists and inhibitors suggests that C4a-mediated cell activation is mediated through PAR1 and PAR4. Our results demonstrate that C4a is a nontraditional agonist for PAR1 and PAR4 whose direct functional effects indicate a potentially significant direct linkage between the complement, coagulation, and endothelial barrier systems. Twit Text FOAVip Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28973891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28973891 #FOAvip English Wikipedia <ref>{{Cite pmid|28973891}}</ref> Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4 #MMPMID28973891 Wang H; Ricklin D; Lambris JD Proc Natl Acad Sci U S A 2017[Oct]; 114 (41): 10948-53 PMID28973891show ga How C4a transduces signaling and generates various biological functions has long been unresolved. Using a cell-based reporter assay, we screened C4a against a panel of 168 known and 73 orphan G protein-coupled receptors and now provide evidence that C4a is a ligand for protease-activated receptor (PAR)1 and PAR4. In human endothelial cells, our assessment of ERK activation and calcium mobilization in the presence of various antagonists and inhibitors suggests that C4a-mediated cell activation is mediated through PAR1 and PAR4. Our results demonstrate that C4a is a nontraditional agonist for PAR1 and PAR4 whose direct functional effects indicate a potentially significant direct linkage between the complement, coagulation, and endothelial barrier systems. äComplement-activation fragment C4a mediates effector functions by bind(epmc).pdf DeepDyve Pubget Overpricing